Evidence map›Paper›PMID 40751831›Full record

ReviewMolecular biology reports2025

The dual role of CD36 in cancer: from lipid metabolism to tumor microenvironment regulation.

Yixuan Yao, Yanyuan Fang, Bin Yuan, Jing Yang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yixuan Yao *Experimental Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, People's Republic of China.
Yanyuan Fang *Experimental Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, People's Republic of China.
Bin YuanDepartment of Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Hefei, 230032, Anhui, People's Republic of China. yuanb_ahmu@163.com.
Jing YangExperimental Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, People's Republic of China. yangjing5@ahmu.edu.cn.

Funding

Basic and Clinical Collaborative Research Enhancement Program of Anhui Medical University 2021xkjT025Natural Research Project of Higher Education of Anhui Province 2023AH050682Shandong Provincial Natural Science Foundation ZR2022LZL003
6 · The paper itself

Abstract

CD36, a class B scavenger receptor dynamically localizing to both plasma and intracellular organelle membranes, plays a crucial role in lipid metabolism regulation. In cancer biology, CD36 exhibits a context-dependent dual role, functioning as either a tumor suppressor or a tumor promoter upon cellular context and tumor microenvironment (TME). Within tumors, CD36 cooperates with autophagy to regulate tumorigenesis, largely through modulation of the TME. The central role of CD36 in regulating lipid homeostasis, along with emerging evidence of its involvement in cancer progression, highlights its therapeutic potential in cancer. This review examines multifaceted roles of CD36 in cancer, focusing on its contributions to dysregulated lipid metabolism, metastasis, dissemination, immune evasion, and therapeutic resistance.

Indexed as

CD36 AntigensLipid MetabolismNeoplasmsTumor MicroenvironmentAnimalsAutophagyHumansCD36 AntigensCD36 protein, humanCancerCD36Immune cellsLipid metabolismTumor microenvironment

Identifiers

PMID40751831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.