Evidence map›Paper›PMID 40751795›Full record

ArticleJournal of endocrinological investigation2025

Integrated analysis of proteomics and metabolomics reveals interactions of energy metabolism and reproduction in hypothalamus of chicken during sexual maturation.

Lingqian Yin, Donghao Zhang, Zhongzhen Lin, Chunlin Yu, Jingjing Li, Feng Xu, Yan Wang, Chaowu Yang, Yiping Liu

Abstract read
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Article in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lingqian Yin *State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, and Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
Donghao Zhang *State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, and Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
Zhongzhen LinState Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, and Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
Chunlin YuAnimal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Animal Science Academy, Chengdu, China.
Jingjing LiSchool of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Feng XuState Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, and Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
Yan WangState Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, and Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
Chaowu YangAnimal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Animal Science Academy, Chengdu, China.
Yiping LiuState Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, and Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China. liuyp578@163.com.

Funding

Natural Science Foundation of Sichuan Province 2024NSFSC0308Sichuan Innovation Team of National Modern Agricultural Industrial Technology System SCCXTD-2024-24Sichuan Science and Technology Program 2023NSFSC1147the earmarked fund for China Agriculture Research System CARS-41-G07
6 · The paper itself

Abstract

backgroundIn poultry, the nutritional status of the body significantly impacts sexual maturation. The hypothalamus, a key neuroendocrine regulator of energy metabolism and sexual maturation, integrates peripheral nutritional signals to modulate reproductive function. However, the precise molecular mechanisms governing this integration remain elusive. This study aimed to investigate the influence of energetic status on hypothalamic function during sexual maturation in chickens.

methodsIn this study, chickens were supplied diets with different energy level. The hypothalamus of chickens at age of first egg and non-laying chickens at same age from different energy level groups were collected. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was performed to determine the proteomics and metabolomics of hypothalamus.

resultsDietary energy levels during the rearing period may modulate hypothalamic function of chicken by altering energy metabolism and amino acid metabolism, as evidenced by the differential expression of hexokinase 1 (HK1), dihydrolipoamide S-acetyltransferase (DLAT), malate dehydrogenase 1 (MDH1), and glutamate, valine, leucine. Furthermore, dietary energy levels alter hypothalamic signaling pathways, with significant differences observed in the proteins, including glutamate receptor 1 (GluR1), cholecystokinin (CCK), proopiomelanocortin (POMC), sphingosine-1-phosphate receptor 1 (S1PR1), relaxin-3 (RFLB) across different energy groups. Notably, GABA and its receptors in the hypothalamus may mediate the regulation of energy metabolism signals on the reproductive center.

conclusionThis study reports that the dietary energy level may affect the function of hypothalamus by altering energy metabolism, amino acid metabolism, and signal transduction. This study provides deeper insights into the impact of energy metabolism on sexual maturation, with implications for both animal husbandry and human medicine.

Indexed as

ChickensEnergy MetabolismHypothalamusMetabolomicsProteomicsReproductionSexual MaturationAnimalsFemaleMaleChickenEnergyHypothalamusLC-MS/MSSexual maturity

Identifiers

PMID40751795

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.