Evidence map›Paper›PMID 40751776›Full record

ArticleArchives of pharmacal research2025

Neuroprotective effects of taurine in a rodent model of parkinson's disease involve modulating astrocyte-mediated inflammation.

Sung Min Moon, Jaehoon Kim, Jaeheon Seol, Seonguk Yang, Duwon Jung, Chang Yup Kim, Chang Seok Kim, Ki Wung Chung, Young-Suk Jung, Seung-Cheol Chang and 2 more

Abstract read
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In one paragraph

Article in Archives of pharmacal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sung Min MoonCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Jaehoon KimCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Jaeheon SeolCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Seonguk YangCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Duwon JungCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Chang Yup KimCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Chang Seok KimCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Ki Wung ChungCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Young-Suk JungCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Seung-Cheol ChangDepartment of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, 46241, Republic of Korea.
Hae Young ChungCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Jaewon LeeCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea. neuron@pusan.ac.kr.ORCID http://orcid.org/0000-0003-3203-2130

Funding

National Research Foundation of Korea (NRF) NRF-2021R1A2C1010091
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons due to oxidative stress and inflammation. Targeting inflammation and oxidative stress offers a promising means of slowing PD progression. Taurine, a naturally occurring amino sulfonic acid, has demonstrated potent antioxidant properties, thereby preventing cell death. While taurine has been studied for its potential to restrain the progression of Alzheimer's disease and mitigate microglial activation, its impact on astrocyte activation in PD models remains underexplored. Here, we found that taurine significantly reduces astroglial activation in MPP

Indexed as

AstrocytesInflammationNeuroprotective AgentsTaurine1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsCells, CulturedDisease Models, AnimalDopaminergic NeuronsDose-Response Relationship, DrugMaleMiceMice, Inbred C57BLOxidative Stress1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineNeuroprotective AgentsTaurineAstrocyteMitochondriaMPTP(1, Methyl, 4, Phenyl, 1,2,3,6, Tetrahydropyridine)NeuroinflammationParkinson’s DiseaseTaurine

Identifiers

PMID40751776

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.