ArticleCalcified tissue international2025
Impacts of Nonenzymatic Glycation Crosslinks in Bone Matrix on the Mechanosensitivity of Osteocyte.
Article in Calcified tissue international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review).Molecular medicine reports · 2026Review
- Programmed cell death in degenerative skeletal diseases: molecular crosstalk and combinatorial therapeutic strategies.Frontiers in cell and developmental biology · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
The products of nonenzymatic glycation (NEG) are a key contributor to various types of osteoporosis, as they affect both the physical properties of bone matrix and the function of osteoblasts and osteoclasts. However, their impact on the mechanosensitivity of osteocytes remains poorly understood. Osteocytes are embedded in lacunar-canalicular system (LCS), and their processes have abundant connections with canalicular matrix to amplify their membrane strain. Thus, we mainly studied the effects of NEG crosslinks in bone matrix on the connections between bone matrix and osteocyte processes, as well as the responses of osteocyte to the mechanical stimulation. To develop the nonenzymatic glycation crosslinked bone matrix in different degrees, we used two concentrations of D-ribose (0.1M and 0.4M) to incubate the decalcified bovine bone slices. Then the osteocyte-like cells (MLO-Y4) were seeded onto these bone slices, and the cell morphology, the mechanical properties of cell processes, the F-actin cytoskeleton, the expression of mechanical sensing elements (integrin αVβ3 and perlecan), were detected to explore the changes in mechanotransduction structure. Followed by, the intracellular Ca
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