Observational studyEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2025
Hyperbaric oxygen therapy is effective and safe for femoral head osteonecrosis: a prospective midterm outcome study.
Observational study in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative efficacy and safety of core decompression, cell-based therapy, hyperbaric oxygen therapy, extracorporeal shock wave therapy, and combined regimens for osteonecrosis of the femoral head: a network meta-analysis.Frontiers in cell and developmental biology · 2026Pooled it
- Osteonecrosis of the Femoral Head: Evolution of Contemporary Management Strategies.Current reviews in musculoskeletal medicine · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe study aims to assess the effect of hyperbaric oxygen therapy (HBOT) on the radiological and clinical outcomes in patients with early Osteonecrosis of the femoral head (ONFH) at mid-term follow-up.
methodsA prospective observational study was conducted on patients with Osteonecrosis of the femoral head (ONFH). ONFH was diagnosed based on plain radiographs and MRI of the bilateral hips. ARCO stages 1-3A of ONFH patients were included with non-traumatic etiologies. Each patient received 5 sessions of HBOT per week for a total of 35 sessions. Repeat MRI was done within 6 weeks of completion of HBOT sessions, at 1 year and 2 years of follow-up. The pre-treatment and last follow-up (2 years) clinical (Harris Hip Scores, VAS Scores) and radiological parameters (JIC Classification, ARCO Staging, Modified Kerboul Angle, Bone marrow edema severity) were compared.
resultsAt the final follow-up, there was a significant improvement in the mean Harris Hip Score (p = 0.001) and VAS Score (p = 0.001). There was also a significant improvement in the JIC classification (p = 0.03), Modified Kerboul Angle (p = 0.001) and Bone marrow edema grading (p = 0.001) at the final follow-up.
conclusionsHBOT provides good clinical and radiological improvement and is an effective, safe, and non-invasive treatment for patients in the early stages of ONFH. Its role in the early collapse stage needs further validation by higher-level, prospective, large-scale RCTs.
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