SynthesisUnited European gastroenterology journal2025
Effectiveness of Gastric Cancer Endoscopic Screening in Intermediate-Risk Countries-A Systematic Review and Meta-Analysis.
Synthesis in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of Gastric Cancer Endoscopic Screening in Intermediate-Risk Countries-A Systematic Review and Meta-Analysis.United European gastroenterology journal · 2025Pooled it
- A pretreatmentTranslational cancer research · 2026Article
- Diagnostic Delay and Mortality Risk in Gastric Cancer During the COVID-19 Pandemic: A Retrospective Tertiary-Center Study.Diagnostics (Basel, Switzerland) · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastric cancer remains a major cause of cancer-related mortality in intermediate-risk countries. Although endoscopic screening is widely implemented in high-risk regions, its effectiveness and economic viability in intermediate-risk settings remain uncertain. This systematic review and meta-analysis evaluated the effectiveness and cost-effectiveness of endoscopic screening in these countries.
methodsA systematic review and meta-analysis was conducted to assess the effectiveness and cost-effectiveness of upper gastrointestinal endoscopic screening by esophagogastroduodenoscopy (EGD) for gastric cancer. Searches were performed in Medline, Scopus, Embase, and Web of Science up to 30 September 2024. Pooled estimates were calculated for the detection of precancerous conditions, gastric cancer (overall and early-stage), and gastric cancer-specific mortality. Subgroup analyses were performed by screening strategy and geographic setting.
resultsThirty-two studies met inclusion criteria-24 on screening effectiveness and eight on cost-effectiveness. Among 404,159 individuals screened, the pooled detection rate for precancerous conditions was 25.5%, for gastric neoplastic lesions 3.3%, and for early-stage cancer among neoplastic cases 91.6%. Gastric cancer-specific mortality was 26.1%, and 5-year survival reached 75.7%. Subgroup analyses of studies using direct EGD versus pre-selection indicated higher detection of precancerous conditions (32.5% vs. 17.0%, p < 0.001) and early-stage cancer (95.8% vs. 87.3%, p < 0.001). Comparing Chinese versus other settings, similar detection rates were found for precancerous conditions (25.3% vs. 26.0%) and early-stage detection (91.5% vs. 100%). Economic analyses suggest that endoscopic screening is cost-effective in intermediate-risk settings, particularly when combined with colorectal screening, with incremental cost-effectiveness ratios within accepted willingness-to-pay thresholds.
conclusionsEndoscopic screening by EGD shows strong potential for early detection of gastric cancer in intermediate-risk countries. However, formal comparative analyses with unscreened populations are lacking, and most survival and mortality data originate from Chinese studies, limiting generalizability. Nevertheless, economic evaluations suggest implementing endoscopic screening-especially when integrated with colorectal screening or guided by risk stratification-could be a feasible and effective strategy.
trial registrationPROSPERO-CRD42024502174.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.