Evidence map›Paper›PMID 40751697›Full record

ArticleJournal of medical virology2025

Seroepidemiology of Human Non-Species A Rotavirus Infections in Valencia, Spain.

Noemi Navarro-Lleó, Silvia Aznar-Córdoba, Dunia Asensio-Cob, Daniel Luque, Javier M Rodríguez, Roberto Gozalbo-Rovira, María Jesús Alcaraz-Soriano, Roberto Cárcamo-Calvo, Jesús Rodríguez-Díaz, Javier Buesa

Abstract read
In one paragraph

Article in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noemi Navarro-LleóFaculty of Medicine, University of Valencia, Valencia, Spain.ORCID 0000-0003-2572-9220
Silvia Aznar-CórdobaFaculty of Medicine, University of Valencia, Valencia, Spain.ORCID 0009-0006-8702-6220
Dunia Asensio-CobInstituto de Salud Carlos III, Centro Nacional de Microbiología, Majadahonda, Spain.ORCID 0000-0003-1221-659X
Daniel LuqueInstituto de Salud Carlos III, Centro Nacional de Microbiología, Majadahonda, Spain.ORCID 0000-0002-0151-6020
Javier M RodríguezCentro Nacional de Biotecnología, CSIC, Cantoblanco, Spain.ORCID 0000-0003-0146-9903
Roberto Gozalbo-RoviraFaculty of Medicine, University of Valencia, Valencia, Spain.ORCID 0000-0003-3427-3800
María Jesús Alcaraz-SorianoHospital Clínico Universitario, INCLIVA, Valencia, Spain.ORCID 0009-0005-2721-7589
Roberto Cárcamo-CalvoFaculty of Medicine, University of Valencia, Valencia, Spain.ORCID 0000-0003-4753-7406
Jesús Rodríguez-DíazFaculty of Medicine, University of Valencia, Valencia, Spain.ORCID 0000-0002-9698-7684
Javier BuesaFaculty of Medicine, University of Valencia, Valencia, Spain.ORCID 0000-0002-3328-3428

Funding

This study was supported by grant PI20/00801 from the Carlos III Health Institute, Spanish Ministry of Science and Innovation. We also acknowledge the Generalitat Valenciana for its financial support by grant ACIF/2020/076 to N.N.-L.
6 · The paper itself

Abstract

Species A rotavirus (RVA) is a major cause of acute gastroenteritis in children. However, three other rotavirus species (RVB, RVC, and RVH) are also able to infect humans. It has been suggested that vaccination against RVA could facilitate an increase of non-A rotavirus infections. We investigated the antibody prevalence against RVA, RVB, RVC, and RVH in 420 human sera collected between 2020 and 2022 from different age groups in Valencia (Spain). Antibody prevalence rates to RVA, RVB, RVC, and RVH were 79.3%, 17.9%, 18.8%, and 14.5%, respectively. Antibody titers against RVA remained consistent across the different age groups, and RVB showed low titers except in younger individuals. RVC-specific antibodies peaked in children 5-10 years of age, whereas RVH exhibited the highest titers in the elderly. The detection of antibodies against non-A rotaviruses in humans in Spain, for the first time against RVB and RVH, highlights the need for their surveillance.

Indexed as

Antibodies, ViralRotavirusRotavirus InfectionsAdolescentAdultAgedChildChild, PreschoolFemaleGastroenteritisHumansInfantInfant, NewbornMaleMiddle AgedSeroepidemiologic StudiesAntibodies, Viralantibodiesnon‐A rotavirusesseroepidemiologyVP2VP6

Identifiers

PMID40751697
PMCPMC12317683

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.