ArticleJournal of the American Chemical Society2025
Dendritic Membranized Coacervate Microdroplets: A Robust Platform for Synthetic-Living Cell Consortia.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Patchy Membrane-Directed Multiphase Complex Coacervation.Journal of the American Chemical Society · 2026Article
- De novo design of peptides localizing at the interface of biomolecular condensates.Nature communications · 2026Article
- Dynamic Covalent Boronate Chemistry forJournal of the American Chemical Society · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bottom-up synthetic biology seeks to construct artificial cells with biomimetic or novel functionalities to uncover the fundamental principles of cellular evolution and drive advances in medicine and bioengineering. Among them, membranized coacervate microdroplets (MCM) uniquely combine a molecularly crowded aqueous interior with a surrounding membrane, both hallmarks of eukaryotic cells. Replicating cellular functions requires synthetic cells to remain structurally stable in biological environments, where ionic strength presents a significant threat to the integrity of complex coacervates. By leveraging the globular and rigid architecture of dendrimers, MCM, composed of oppositely charged small dendrimers and polypeptides─further stabilized by a charged PEG-dendritic copolymer assembled at the periphery─exhibits a critical salt concentration more than twice that of coacervates formed from polypeptides or branched polyelectrolytes with significantly higher degrees of polymerization. This highlights the enhanced robustness of dendritic MCM under physiological conditions and their suitability as synthetic cells in biological media. By mimicking key cell-like behavior such as efficient enzyme encapsulation (irrespective of the isoelectric point), fast internal dynamics, and chemical communication, dendritic MCM emerge as a promising synthetic cell platform for the selective delivery of therapeutic enzymes. In addition, their ability to engage in signal transduction pathways within synthetic-natural cell consortia, enabling responses to extracellular cues via chemical signaling, paves their way in tissue engineering and regenerative medicine.
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Registered trials
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