ArticleCytoskeleton (Hoboken, N.J.)2026
Centrosome Protein CCDC81 Promotes Ciliogenesis.
Article in Cytoskeleton (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Centrosome Protein CCDC81 Promotes Ciliogenesis.Cytoskeleton (Hoboken, N.J.) · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In animal cells, centrosomes function as the microtubule-organizing centers; their presence is essential for mitosis and for assembling various cilia-both primary and motile. Here, we identified coiled-coil domain containing 81 (CCDC81) located at the centrosome through its 301-505 aa. Using bioinformatics approaches, we constructed a Neighbor-Joining phylogenetic tree. We also analyzed the conservation of the CCDC81 protein sequence. The results reveal a high degree of conservation in mammals, implying a potentially vital biological role for CCDC81. Silencing of CCDC81 resulted in a decrease in both the frequency and length of primary cilia, yet it exerted no significant impact on centriole number. Examining CCDC81 tissue distribution in mice revealed markedly elevated Ccdc81 mRNA levels in testis, lung, trachea, and fallopian tubes-tissues characterized by abundant motile cilia. Ccdc81 knockout mice were generated using CRISPR/Cas9 technology. Over a six-week period, body weight measurements of knockout mice showed no significant abnormalities. Our research results suggest that CCDC81 is indispensable for the formation of primary cilia and plays a role in the function of motile cilia.
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Registered trials
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