ArticleJournal of neurochemistry2025
In Vivo Cortical Microstructure: Relationships With Tauopathy and Cognitive Impairment in the Elderly.
Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Advanced diffusion MRI tract signatures in Alzheimer's disease, dementia with Lewy bodies, and the FTD/PPA spectrum.NeuroImage · 2026Review
- Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.Human brain mapping · 2026Article
- Neurite orientation dispersion and density imaging in stroke: current applications, limitations, and future directions.Frontiers in human neuroscience · 2026Review
- In Vivo Cortical Microstructure: Relationships With Tauopathy and Cognitive Impairment in the Elderly.Journal of neurochemistry · 2025Article
- Age-Related Alterations in Gray Matter Microstructure in Older People With Remitted Major Depression at Risk for Dementia.Biological psychiatry global open science · 2024Article
- White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease.Neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Positron Emission Tomography (PET) of tau is considered "the" indicator of Alzheimer's pathology. However, non-PET proxies would be helpful for wider accessibility. We used Neurite Orientation Dispersion and Density Imaging (NODDI)-derived indices (i.e., orientation dispersion [ODI], neurite density [NDI], and free-water [fISO]) to determine relationships of gray matter microstructure with tau and cognitive impairment. We assessed the fit between NODDI indices, cortical thickness/subcortical volume (CT/ScVol), and tau via multiple factor analysis (MFA) using data from 80 participants from the ADNI-3 dataset with overlapping multishell diffusion-weighted and tau-PET scans ([
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.