Evidence map›Paper›PMID 40751359›Full record

ArticleJournal of diabetes2025

Does Metabolic Status Associate With IVF Outcomes in Women Within Similar Body Mass Index Category: Evidence From a Large Cohort Study.

Lin Ding, Xiaojing Lin, Peipei Pan, Yan Li, Wei Chen, Liying He, Yunsheng Xu, Hsun-Ming Chang, Haiyan Yang, Guiquan Wang and 1 more

Abstract read
In one paragraph

Article in Journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lin DingPost-doctoral Mobile Research Station, Shandong University of Traditional Chinese Medicine, Jinan, China.
Xiaojing LinReproductive Medicine Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Peipei PanReproductive Medicine Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yan LiReproductive Medicine Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Wei ChenReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Liying HeReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Yunsheng XuPost-doctoral Mobile Research Station, Shandong University of Traditional Chinese Medicine, Jinan, China.
Hsun-Ming ChangDepartment of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan.
Haiyan YangReproductive Medicine Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Guiquan WangDepartment of Reproductive Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China.
Liangshan MuReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-2498-3825

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWhether diverse metabolic statuses within a similar body mass index (BMI) category associate with different in vitro fertilization (IVF) outcomes.

designA retrospective cohort study.

settingWenzhou, Zhengjiang Province, China. POPULATION: This retrospective cohort study prescreened 16 458 women who underwent their first IVF and fresh embryo transfer cycle between January 2010 and December 2021.

methodsMetabolic status was assessed using the National Cholesterol Education Program-Adult Treatment Panel III criteria. Patients were then categorized into six groups: metabolically healthy normal weight, metabolically unhealthy normal weight, metabolically healthy overweight, metabolically unhealthy overweight, metabolically healthy obese, and metabolically unhealthy obese.

main outcome measuresThe primary outcome was live birth rate.

resultsRegarding live birth, rates in normal weight women were initially lower for metabolically unhealthy normal weight versus metabolically healthy normal weight (44.6% vs. 48.6%), but this was not significant after multivariate adjustment. In obese women, live birth rates were similar between metabolically unhealthy obese and metabolically healthy obese (41.5% vs. 43.9%), with no adjusted difference. For secondary outcomes, metabolically unhealthy normal weight patients had lower biochemical pregnancy rates than metabolically healthy normal weight (OR: 0.86, 95% CI: 0.76-0.98); high blood pressure was a significant risk factor for this outcome in metabolically unhealthy normal weight (OR: 0.84, 95% CI: 0.72-0.98).

conclusionOur findings indicated that different cardio-metabolic risk factors but a similar BMI category may have limited adverse effects on live birth rate.

Indexed as

Body Mass IndexFertilization in VitroObesityAdultChinaFemaleHumansLive BirthOverweightPregnancyPregnancy OutcomePregnancy RateRetrospective Studiesin vitro fertilizationlive birth ratemetabolically healthy obesemetabolically unhealthy obesemiscarriage rate

Identifiers

PMID40751359
PMCPMC12317112

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.