ArticleActa paediatrica (Oslo, Norway : 1992)2025
Urinary Calcium and Phosphorus Excretion in Vitamin D-Sufficient Preterm Infants: Establishing Age-Specific Normative Data.
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Comparative effectiveness of low-dose versus high-dose vitamin D on bone metabolic markers in preterm infants: a retrospective cohort study.Translational pediatrics · 2026Article
- Daily clinical markers in metabolic bone disease of prematurity.Pediatric research · 2026Article
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Authors and funding
6 authors.
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Abstract
aimThis study evaluated urinary calcium (Ca) and phosphorus (P) excretion in very low birth weight infants ( < 1500 g, VLBW) without severe morbidity, treated with methylxanthines.
methodsEighty-one VLBW infants were analysed. Urinary Ca and P and their creatinine ratios were measured biweekly until day 56. Serum parathyroid hormone (PTH), 25-hydroxyvitamin D [25-(OH)D], total Ca, P and alkaline phosphatase (ALP) were assessed. Bone densitometry was performed before discharge.
resultsIn 254 urine samples, urinary Ca and P excretion differed significantly from their creatinine ratios. Vitamin D status influenced urinary mineral excretion, likely via PTH regulation, but did not affect serum Ca, P, or ALP. Normative data were established only for infants with serum 25-(OH)D > 50 nmol/L. Due to age-related variability, a single reference range was not possible.
conclusionsWe provide age-specific normative data for urinary Ca and P excretion in healthy VLBW infants with sufficient vitamin D. Urinary mineral excretion varies significantly with postnatal age, emphasising the need for individualised monitoring to prevent metabolic bone disease of prematurity. Vitamin D status is crucial for calcium-phosphorus homeostasis, with sufficient levels linked to increased Ca excretion and relative P depletion from the 2 month of life.
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