Evidence map›Paper›PMID 40751324›Full record

ArticlePediatric blood & cancer2025

Statewide Academic Performance of High School Students With Sickle Cell Disease.

Andrew M Heitzer, Meredith Ray, Andrew Wiese, Judy Dudley, Kelly M Harris, Allison A King, Jane S Hankins, William O Cooper, Matthew P Smeltzer, Robert Davis

Abstract read
In one paragraph

Article in Pediatric blood & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew M HeitzerDepartment of Psychology & Biobehavioral Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0009-0001-0365-0338
Meredith RayDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, The University of Memphis, Memphis, Tennessee, USA.
Andrew WieseDepartment of Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Judy DudleyDepartment of Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kelly M HarrisProgram in Occupational Therapy and Departments of Pediatrics and Medicine, Washington University, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-5282-4226
Allison A KingProgram in Occupational Therapy and Departments of Pediatrics and Medicine, Washington University, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-1951-6176
Jane S HankinsDepartments of Global Pediatric Medicine and Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0003-4439-7321
William O CooperDepartment of Pediatrics and Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Matthew P SmeltzerDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, The University of Memphis, Memphis, Tennessee, USA.
Robert DavisCenter in Biomedical Informatics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Funding

Washington University K12 Program in T4 Implementation ResearchK12HL137942 · NHLBI · WASHINGTON UNIVERSITY · PI DAVILA-ROMAN, VICTOR G. · 2017 to 2021
$3.1M
(SCANS) Sickle Cell Anemia Neurodevelopmental Screening - Mentoring and Research in Patient Oriented ResearchK24HL148305 · NHLBI · WASHINGTON UNIVERSITY · PI Allison A King · 2019 to 2026
$706k
Benzodiazepine restrictions and the prevention of overdoses and other harmsK01DA051683 · NIDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WIESE, ANDREW DAVID · 2021 to 2024
$688k
School Readiness Intervention for Preschool Children with Sickle Cell DiseaseK23HL166697 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Andrew M Heitzer · 2023 to 2026
$648k
CDC HHSNHLBI NIH HHS K12 HL137942NHLBI NIH HHS K23 HL166697NHLBI NIH HHS K24 HL148305NIDA NIH HHS K01 DA051683
6 · The paper itself

Abstract

purposeAmong patients with sickle cell disease (SCD), poor academic attainment in adolescence is associated with a greater frequency of acute care visits and a poorer health-related quality of life in adulthood. We compared the academic performance of high school students with SCD to students without SCD after controlling for race and sex.

methodsThis retrospective cohort study was constructed based on the Tennessee Medicaid program claims data and Tennessee Department of Education Race to the Top educational data from October 1, 2007 to September 30, 2019. For every ninth grade student with SCD identified, eight students without SCD were identified. Academic achievement was measured using rates of proficiency on end-of-course assessments. The number of days absent per school year, grade retention, and school withdrawal were used as measures of academic attainment.

resultsThe analysis included 498 students with SCD and 3188 students without SCD. After race and sex were adjusted for, students with SCD had English proficiency odds of 0.8 times (95% confidence interval [CI]: 0.7-0.9; p < 0.001) those of students without SCD. Students with SCD were 1.2 times (95% CI: 1.0-1.5; p = 0.045) more likely to be retained in the ninth grade. The effect of SCD on grade retention was mediated by days absent from school (odds ratio for indirect effect, 1.18 (95% CI: 1.1-1.26; p < 0.0001). DISCUSSION: SCD negatively affects academic performance partly through frequent school absence.

Indexed as

Academic PerformanceAcademic SuccessAnemia, Sickle CellQuality of LifeStudentsAdolescentFemaleFollow-Up StudiesHumansMalePrognosisRetrospective StudiesSchoolsTennesseeUnited Statesacademiceducationhigh schoolneurocognitivesickle cell

Identifiers

PMID40751324
PMCPMC12461487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.