Observational studyAlimentary pharmacology & therapeutics2026
Impact of Frailty on the Prognosis of Patients With Liver Cirrhosis Undergoing Insertion of a TIPS.
Observational study in Alimentary pharmacology & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Benefits and Limitations of Transjugular Intrahepatic Portosystemic Shunts (TIPS) in Patients With Decompensated Liver Cirrhosis
Prediction of Post-TIPS Hepatic Encephalopathy in Patients With Liver Cirrhosis
Who cites it
2 citing papers in PubMed.
- Sarcopenia Predicts Mortality and Hepatic Encephalopathy After TIPS in Older Adults With Cirrhosis and Improves Prognostic Scores.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Navigating TIPS in the era of ageing and metabolic comorbidity: a contemporary narrative review of risk, resilience, and outcomes.Gastroenterology report · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
BACKGROUND AND
aimsFrailty is associated with a poorer prognosis of patients awaiting liver transplantation. Data on the impact of frailty on prognosis after transjugular intrahepatic portosystemic shunt (TIPS)-insertion in patients with cirrhosis and the influence of TIPS on longitudinal changes in frailty are lacking.
methodsWe retrospectively analysed data of 123 prospectively recruited patients with cirrhosis in Mainz and Hannover prior to elective TIPS insertion and monitored them for death/liver transplantation or post-TIPS overt hepatic encephalopathy (OHE). Patients underwent testing with the Liver Frailty Index (LFI) prior to TIPS insertion as well as 1, 3 and 6 months after TIPS placement.
resultsMedian LFI prior to TIPS insertion was 4.32 (interquartile range: 3.78-4.88). 53% of patients who were frail at baseline and still alive at 6 months improved to prefrail status within 6 months of TIPS insertion. Higher LFI and younger age were associated with a decrease in LFI within 6 months. During follow-up, 40 patients developed post-TIPS OHE and 30 patients died or received a liver transplantation. There was no significant association between LFI as a metric variable and post-TIPS OHE or liver transplantation/death. However, patients with LFI values in the lowest quartile had a significantly better transplantation-free survival.
conclusionsTIPS insertion seems to improve physical functioning, as indicated by a decreasing LFI, but only in patients with a poor performance in LFI prior to TIPS. Conducting LFI prior to elective TIPS insertion can identify those with an excellent prognosis. However, frailty should not be considered a contraindication for TIPS.
trial registrationClinicalTrials.gov identifier: NCT05466669 and NCT04801290.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.