Evidence map›Paper›PMID 40751256›Full record

ArticleBMC pulmonary medicine2025

Outcomes of adult empyema thoracis cases managed in a tertiary hospital in Uganda: a retrospective cohort study.

Michael Mwesige, Paul Otim, Richard N Iranya, John Paul Magala, Timothy K Makumbi

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Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Michael MwesigeDepartment of Surgery, College of Health Sciences, Makerere University, Kampala, Uganda.
Paul OtimDepartment of Surgery, Soroti University, Soroti, Uganda.
Richard N IranyaDepartment of Surgery, Moyo General Hospital, Moyo, Uganda. r.iranya9@gmail.com.
John Paul MagalaDepartment of Surgery, College of Health Sciences, Makerere University, Kampala, Uganda.
Timothy K MakumbiDepartment of Surgery, College of Health Sciences, Makerere University, Kampala, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmpyema thoracis is a debilitating illness observed in all age groups. Recent data indicate increasing incidence rates and worsening outcomes. However, published data on the outcomes of empyema thoracis cases in our setting are scarce.

objectiveThis study evaluated outcomes and associated factors for adult empyema thoracis patients managed at a single tertiary center in Uganda.

methodsWe reviewed the file records of patients 18 years or older who were managed for empyema thoracis at Mulago National Referral Hospital from January 2017 to December 2021. Sociodemographic data, comorbidities, clinical parameters at admission, and management strategies were reviewed. The outcomes of interest were in-hospital mortality and the need for re-intervention. A multivariate logistic regression model was used to identify independent factors associated with the need for re-intervention and in-hospital mortality.

resultsA total of 200 case files were analyzed, and 123 (61.5%) of the cases were males. The median age of the cohort was 33 years (IQR = 21). The in-hospital mortality rate was 10.5% (21 patients), and 23.5% (47 patients) required one or more re-interventions. Advancing age (adjusted OR = 1.04 (1.01-1.08)) and non para-pneumonic underlying etiology (adjusted OR = 11.45 (2.74-47.89)) were independently associated with increased in-hospital mortality, whereas delayed empyema drainage (adjusted OR = 2.97 (1.33-6.67)) and underlying non para-pneumonic etiology (adjusted OR = 3.83 (1.45-10.10.10)) significantly increased the odds of the need for re-intervention in management.

conclusionThe in-hospital mortality and re-intervention rates for empyema thoracis were high in our study. Particularly at-risk groups for these poor outcomes are those with advanced age, non para-pneumonic empyema thoraces, and delayed initial intervention.

Indexed as

DrainageEmpyema, PleuralAdultAge FactorsFemaleHospital MortalityHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisRetreatmentRetrospective StudiesRisk FactorsTertiary Care CentersTreatment OutcomeAnd re-interventionEmpyema thoracisIn-hospital mortalityOutcomes

Identifiers

PMID40751256
PMCPMC12315433

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.