ArticleRadiation oncology (London, England)2025
Early prediction of histopathological response of locally advanced rectal cancer after 1 week of preoperative radiochemotherapy using
Article in Radiation oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of artificial intelligence-assisted 18f-fdg pet/ct for predicting pathological complete response to neoadjuvant chemotherapy in breast cancer: a systematic review and meta-analysis.Annals of nuclear medicine · 2026Pooled it
- Prediction of histological response by PET-CT after 2 weeks of neoadjuvant chemo-radiotherapy for rectal cancer: a prospective clinical trial.Journal of gastrointestinal oncology · 2026Article
- Clinical utility and future directions of FDG-PET in rectal cancer management.Annals of nuclear medicine · 2026Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeoadjuvant (preoperative) radiochemotherapy (nRCT) is a standard of care in locally advanced rectal cancer (LARC). Several studies have shown that the decline in
methodsThirty-eight patients with LARC who received standard nRCT followed by radical surgery were enrolled. Metabolic response, evaluated by the percent of change in maximum standardized uptake value (ΔSUVmax%), measured by PET-CT imaging at baseline and on day 8 of nRCT, was compared with the histopathological response at surgery. Histopathological response was assessed by pathological complete response (pCR) and, when possible, by tumor regression grade (TRG). We also examined the association of baseline and second PET-CT parameters with pCR and TRG at surgery.
trial registration0239-07-RMC, registration date: 21/08/2007.
resultsNeither pCR nor TRG were associated with any change in PET-CT parameters after 1 week of treatment. Baseline metabolic tumor volume (MTV) was the only PET-CT parameter with a statistically significant association with pCR (p = 0.002), but not with TRG (p = 0.08).
conclusionsA decrease in SUVmax after 1 week of nRCT for LARC failed to predict the achievement of pCR or TRG in the post-nRCT surgical specimen, underlining the importance of validation clinical trials. Nonetheless, our findings on the correlation between baseline MTV and histopathological response can, if confirmed, be a useful tool for treatment selection. Validation in a larger independent cohort is planned.
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