GbTRB1 binds telomeric DNA in Ginkgo biloba.

Yu Sun, Huimin Zhang, Yirong Zou, Xueqin Guo, Yuping Feng, Di Liu, Hai Lu

Abstract read

In one paragraph

Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu Sun *State Key Laboratory of Tree Genetics and Breeding, National Engineering Research Center of Tree Breeding and Ecological Restoration, Beijing Forestry University, Beijing, 100083, China.

Huimin Zhang *State Key Laboratory of Tree Genetics and Breeding, National Engineering Research Center of Tree Breeding and Ecological Restoration, Beijing Forestry University, Beijing, 100083, China.

Yirong ZouState Key Laboratory of Tree Genetics and Breeding, National Engineering Research Center of Tree Breeding and Ecological Restoration, Beijing Forestry University, Beijing, 100083, China.

Xueqin GuoState Key Laboratory of Tree Genetics and Breeding, National Engineering Research Center of Tree Breeding and Ecological Restoration, Beijing Forestry University, Beijing, 100083, China.

Yuping FengState Key Laboratory of Tree Genetics and Breeding, National Engineering Research Center of Tree Breeding and Ecological Restoration, Beijing Forestry University, Beijing, 100083, China.

Di LiuState Key Laboratory of Tree Genetics and Breeding, National Engineering Research Center of Tree Breeding and Ecological Restoration, Beijing Forestry University, Beijing, 100083, China. liudi@bjfu.edu.cn.

Hai LuState Key Laboratory of Tree Genetics and Breeding, National Engineering Research Center of Tree Breeding and Ecological Restoration, Beijing Forestry University, Beijing, 100083, China. luhai1974@bjfu.edu.cn.ORCID http://orcid.org/0000-0003-0937-954X

Funding

the Emergency Open Competition Project of National Forestry and Grassland Administration 202303

6 · The paper itself

Abstract

Telomere-binding proteins play a crucial role in maintaining the stability of telomere structures. In this study, we found that GbTRB1, a double-stranded telomere-binding protein, can bind telomeric DNA., plays a pivotal role in telomere complex stability in Ginkgo biloba. The Myb domain in GbTRB1 is a key domain for binding to the telomeric dsDNA sequences, while the H1/H5 histone domain is a key domain for binding to the telomeric ssDNA sequences. We the first time reported that GbTRB1 can bind telomeric DNA. GbTRB1 interacts with GbTERT, the telomerase subunit, in vivo and in vitro. The telomere length was increased in GbTRB1-overexpressed transgenic Arabidopsis, suggesting GbTRB1 plays an important role in maintaining telomere stability and telomere length. Our results showed GbTRB1 can bind telomeric DNA. and interact with telomerase. This unusual dual role of GbTRB1 may partly explain the longevity mechanisms observed in Ginkgo biloba.

Indexed as

DNA, PlantGinkgo bilobaPlant ProteinsTelomereTelomere-Binding ProteinsArabidopsisPlants, Genetically ModifiedProtein BindingTelomeraseDNA, PlantPlant ProteinsTelomeraseTelomere-Binding ProteinsDouble-stranded telomeric DNAGbTRB1Single-stranded telomeric DNA, telomeraseTelomere-binding proteins

Identifiers

PMID40751121

DOI10.1186/s12870-025-06668-7

PMCPMC12315454

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.