ArticleScientific reports2025
Medication adherence among children with heart failure at the University of Gondar Comprehensive Specialized Hospital Gondar Northwest Ethiopia.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Children with heart failure take multiple medications, and adherence to the medicines plays a pivotal role in attaining maximal therapeutic benefits. However, the exact prevalence of medication adherence among children with heart failure is not well documented, especially in developing countries. Therefore, this study was conducted to assess the magnitude of poor medication adherence and its associated factors among children with heart failure. An institutional-based cross-sectional study was conducted among children with heart failure visiting the University of Gondar Comprehensive Specialized Hospital Pediatric Cardiac Follow-Up Clinic from January 1 to May 30, 2022. A pre-tested & structured questionnaire and medical record review were used for data collection. The data-collecting questionnaire includes socio-demographic characteristics, clinical parameters, and recorded medication. A systemic random sampling technique was used to select 203 participants from the sampling frame. Binary and multivariable logistic regressions were employed to determine factors associated with poor medication adherence. The statistical association between dependent and independent variables was declared at a p-value of < 0.05. A total of 203 respondents were included in the final analysis with a 93.5% response rate with male-to-female ratio of nearly 1:1. The mean age of the study participants was 9.53(± 5.2) years ranging from 3 months to 18 years. The magnitude of poor adherence was 23.15% (17.3-29.0%). Not having health insurance (AOR = 4.402, 95%CI, 1.95-9.938, P = 0.000), living far from hospital (AOR = 3.171, 95%CI, 1.373-7.327, P = 0.007), rural residence (AOR = 2.638, 95%CI, 1.092-6.369, P = 0.031) and low household income (AOR = 5.11, 95%CI 1.994-13.098, P = 0.001) were significantly associated with poor medication adherence. Nearly one-quarter of children with heart failure poorly adhere to their cardiovascular medications. The current study investigated that lack of health insurance, living far from the hospital, rural residence, and low household income were significantly associated with poor medication adherence. Providing follow-up care at hospitals closer to patients' residence areas could improve medication adherence. In addition, awareness creation and access to health insurance are recommended to decrease poor medication adherence at the community level.
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