Trial reportScientific reports2025
Intraarticular injection of the stromal vascular fraction for the treatment of knee osteoarthritis a prospective randomized controlled clinical trial.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intra-articular adipose-derived cell therapies for knee osteoarthritis: a systematic review of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Temporal Hierarchy of Hydrogels and Orthobiologic Therapies for Knee Osteoarthritis.Gels (Basel, Switzerland) · 2026Review
- Mechanical isolation of stromal vascular fraction using a spiral-based device: cellular outcomes and point-of-care workflow considerations.Journal of biological engineering · 2026Article
- Challenges and Strategies in Hydrogel-Based Cartilage Regeneration.Gels (Basel, Switzerland) · 2026Review
- Stromal Vascular Fraction Across Different Clinical Indications: A Pro-RegenerativeJournal of clinical medicine · 2026Article
- Cycloastragenol attenuates osteoarthritis by restoring chondrocyte senescence via the NRF2/NF-κB signaling axis.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Currently, conservative treatment for knee osteoarthritis (KOA) has limited efficacy, and autologous adipose-derived stromal vascular fraction (SVF) knee injections, a novel treatment approach, are receiving widespread attention. Our study aimed to explore the efficacy and safety of SVF treatment for KOA patients. This randomized controlled trial sought to assess the efficacy and safety of intra-articular SVF injections for the treatment of KOA, both as an independent intervention and in conjunction with conventional rehabilitation. Sixty-six KOA subjects were randomly divided into three groups: (1) the SVF group received a single SVF intra-articular knee injection; (2) the control group received conventional rehabilitation treatment (muscle strength training, interferential therapy, and manual therapy, 5 times a week for a total of 4 weeks); and (3) the combination therapy group received a single SVF intra-articular knee injection followed by conventional rehabilitation treatment. Outcomes were assessed during a 12-month follow-up period, with outcome measures including the visual analog scale for pain; the Western Ontario and McMaster Universities Osteoarthritis Index for pain, stiffness, and function; range of motion (ROM); and the occurrence of complications. A total of 62 patients completed the follow-up. There were no significant baseline differences among the groups. The results after treatment revealed that the SVF group and the combination therapy group significantly outperformed the control group in terms of pain relief, improvement in knee function, and increased mobility (P < 0.05). Throughout the treatment and follow-up periods, no severe adverse events were reported in any of the three groups (P > 0.05). The results of this study indicate that SVF intra-articular injection alone or in combination with conventional rehabilitation methods can significantly improve pain, knee function, and stiffness in KOA patients, with the therapeutic effects continuing to increase over a 12-month period. SVF treatment provides an effective and safe therapeutic option for KOA patients and has important implications for future clinical practice and research.
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