ArticleInsights into imaging2025
Deep learning-based super-resolution US radiomics to differentiate testicular seminoma and non-seminoma: an international multicenter study.
Article in Insights into imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- From Testis to Retroperitoneum: The Role of Radiomics and Artificial Intelligence for Primary Tumors and Nodal Disease in Testicular Cancer: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Machine learning of multiparametric MRI radiomics preoperatively distinguishes testicular seminoma from non-seminoma: a multicenter study.Abdominal radiology (New York) · 2026Article
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15 authors.
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Abstract
objectivesSubvariants of testicular germ cell tumor (TGCT) significantly affect therapeutic strategies and patient prognosis. However, preoperatively distinguishing seminoma (SE) from non-seminoma (n-SE) remains a challenge. This study aimed to evaluate the performance of a deep learning-based super-resolution (SR) US radiomics model for SE/n-SE differentiation. MATERIALS AND
methodsThis international multicenter retrospective study recruited patients with confirmed TGCT between 2015 and 2023. A pre-trained SR reconstruction algorithm was applied to enhance native resolution (NR) images. NR and SR radiomics models were constructed, and the superior model was then integrated with clinical features to construct clinical-radiomics models. Diagnostic performance was evaluated by ROC analysis (AUC) and compared with radiologists' assessments using the DeLong test.
resultsA total of 486 male patients were enrolled for training (n = 338), domestic (n = 92), and international (n = 59) validation sets. The SR radiomics model achieved AUCs of 0.90, 0.82, and 0.91, respectively, in the training, domestic, and international validation sets, significantly surpassing the NR model (p < 0.001, p = 0.031, and p = 0.001, respectively). The clinical-radiomics model exhibited a significantly higher across both domestic and international validation sets compared to the SR radiomics model alone (0.95 vs 0.82, p = 0.004; 0.97 vs 0.91, p = 0.031). Moreover, the clinical-radiomics model surpassed the performance of experienced radiologists in both domestic (AUC, 0.95 vs 0.85, p = 0.012) and international (AUC, 0.97 vs 0.77, p < 0.001) validation cohorts.
conclusionsThe SR-based clinical-radiomics model can effectively differentiate between SE and n-SE. CRITICAL RELEVANCE STATEMENT: This international multicenter study demonstrated that a radiomics model of deep learning-based SR reconstructed US images enabled effective differentiation between SE and n-SE. KEY POINTS: Clinical parameters and radiologists' assessments exhibit limited diagnostic accuracy for SE/n-SE differentiation in TGCT. Based on scrotal US images of TGCT, the SR radiomics models performed better than the NR radiomics models. The SR-based clinical-radiomics model outperforms both the radiomics model and radiologists' assessment, enabling accurate, non-invasive preoperative differentiation between SE and n-SE.
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