Evidence map›Paper›PMID 40750903›Full record

ArticleClinical epigenetics2025

Association of epigenetic aging with plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in Hispanic/Latino adults.

Myriam Fornage, Wassim Tarraf, Martha L Daviglus, Charles DeCarli, Kevin A Gonzalez, Carmen R Isasi, Sayaka Kuwayama, Melissa Lamar, Bonnie E Levin, Humberto Parada and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Epigenetic aging and blood based neurodegeneration markers in LASI-DAD.The journal of prevention of Alzheimer's disease · 2026
    Article
  2. Article
  3. APOE and plasma AD biomarkers: The role of genetic ancestry in Hispanics/Latinos.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Review
  5. Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Myriam FornageInstitute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, 1825 Pressler Street #530F, Houston, TX, 77030, USA. Myriam.Fornage@uth.tmc.edu.
Wassim TarrafInstitute of Gerontology & Department of Healthcare Sciences, Wayne State University, 87 East Ferry Street, Detroit, MI, 48202, USA.
Martha L DaviglusInstitute for Minority Health Research, University of Illinois Chicago, 1853 West Polk Street, Chicago, IL, 60612, USA.
Charles DeCarliDepartment of Neurology, University of California, Davis, 4860 Y Street, Sacramento, CA, 95817, USA.
Kevin A GonzalezDepartment of Neurosciences, University of California, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Carmen R IsasiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Sayaka KuwayamaDepartment of Neurosciences, University of California, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Melissa LamarDepartment of Psychiatry and Behavioral Sciences, Rush University, 1750 W. Harrison Street, Chicago, IL, 60612, USA.
Bonnie E LevinDepartment of Neurology and Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, 1150 Northwest 14Th Street, Miami, FL, 33136, USA.
Humberto ParadaDivision of Epidemiology and Biostatistics, School of Public Health, San Diego State University, 5500 Campanile Drive, San Diego, CA, 92192, USA.
Alberto R RamosDepartment of Neurology and Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, 1150 Northwest 14Th Street, Miami, FL, 33136, USA.
Tatjana RundekDepartment of Neurology and Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, 1150 Northwest 14Th Street, Miami, FL, 33136, USA.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN, 55455, USA.
Hector M GonzálezDepartment of Neurosciences, University of California, 9500 Gilman Drive, La Jolla, CA, 92093, USA.

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Neurocognitive aging, MCI and Alzheimer's disease DNA methylation among diverse LatinosRF1AG061022 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FORNAGE, MYRIAM, GONZALEZ, HECTOR M · 2019 to 2019
$6.6M
NHGRI NIH HHS HHSN268201300003CNHLBI NIH HHS HHSN268201300003INHLBI NIH HHS HHSN268201300003I / N01- HC-65236NHLBI NIH HHS N01 HC065236NIA NIH HHS RF1 AG061022NIA NIH HHS RF1AG061022NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

backgroundBlood-based biomarkers hold significant promise for the early detection and diagnosis of Alzheimer's disease (AD) and other dementias. Age-related changes in blood levels of AD biomarkers are well-documented but poorly understood. Epigenetic clocks are mathematical models based on DNA methylation patterns that reflect various aspects of the multidimensional aging process. We investigated the associations of epigenetic aging with five blood-based AD biomarkers in 2656 Hispanic/Latino adults (mean age 62.5 years; 65% females) from the Hispanic Community Health Study/Study of Latinos. We used multivariable linear regression models to estimate the associations of acceleration in each of five epigenetic clocks with each biomarker in the total sample and in sex-specific strata, controlling for chronological age, sex (except in sex-stratified analyses), Hispanic/Latino background, recruitment site, risk factors, and comorbid medical conditions.

resultsThere were varying strengths of association between acceleration of the clocks and the plasma biomarkers. There were significant associations of acceleration in all epigenetic clocks with higher plasma levels of neurofilament light chain (NfL) (Beta = 0.0045 to 0.0193; P = 0.022 to 4.9 × 10

conclusionsEpigenetic age acceleration is associated with circulating biomarkers of AD in Hispanic/Latino adults. The second-generation clock PC-PhenoAge showed strong and consistent associations across all biomarkers, and thus may reflect biological processes most relevant to age-related changes in AD biomarkers. Considering sex differences in the relationship between biological aging and circulating AD biomarkers is paramount.

Indexed as

AgingAlzheimer DiseaseAmyloid beta-PeptidesEpigenesis, GeneticHispanic or LatinoNeuroinflammatory Diseasestau ProteinsAgedBiomarkersDNA MethylationFemaleHumansMaleMiddle AgedNeurofilament ProteinsAmyloid beta-PeptidesBiomarkersneurofilament protein LNeurofilament Proteinstau ProteinsAlzheimer’s diseaseEpigenetic aging, blood-based biomarkersEpigenetic clocksHispanic/Latino

Identifiers

PMID40750903
PMCPMC12315259

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.