Evidence map›Paper›PMID 40750837›Full record

ArticleScientific reports2025

Harnessing prebiotic formamide chemistry: a novel platform for antiviral exploration.

Maria Grazia Martina, Chiara Vagaggini, Elena Dreassi, Marta De Angelis, Lucia Nencioni, Filippo Dragoni, Federica Giammarino, Adele Boccuto, Maurizio Zazzi, Ilaria Vicenti and 1 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria Grazia MartinaDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Viale delle Scienze, 27/A, Parma, 43124, Italy.
Chiara VagagginiDepartment of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, Siena, 53100, Italy.
Elena DreassiDepartment of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, Siena, 53100, Italy.
Marta De AngelisDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, P.le Aldo Moro 5, Rome, 00185, Italy.
Lucia NencioniDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, P.le Aldo Moro 5, Rome, 00185, Italy.
Filippo DragoniDepartment of Medical Biotechnologies, University of Siena, Viale Bracci 16, Siena, 53100, Italy.
Federica GiammarinoDepartment of Medical Biotechnologies, University of Siena, Viale Bracci 16, Siena, 53100, Italy.
Adele BoccutoDepartment of Medical Biotechnologies, University of Siena, Viale Bracci 16, Siena, 53100, Italy.
Maurizio ZazziDepartment of Medical Biotechnologies, University of Siena, Viale Bracci 16, Siena, 53100, Italy.
Ilaria VicentiDepartment of Medical Biotechnologies, University of Siena, Viale Bracci 16, Siena, 53100, Italy.
Marco RadiDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Viale delle Scienze, 27/A, Parma, 43124, Italy. marco.radi@unipr.it.

Funding

European Commission PE00000007Ministero dell'Università e della Ricerca 2017BMK8JR
6 · The paper itself

Abstract

Viruses and host cells are intricately connected through a shared "chemical language" that may trace back to the prebiotic chemistry of early Earth. In this study, we present an innovative platform for antiviral exploration inspired by this primordial chemical framework. By "doping" the formamide-based prebiotic chemistry model with orotic acid derivatives, we generated complex, non-natural chemical mixtures capable of disrupting the replication of multiple viruses with minimal or no toxicity for eukaryotic cells. This strategy underscores the potential of an evolution-inspired approach in antiviral discovery, offering a novel avenue for identifying new agents with unconventional mechanisms that might elude traditional discovery methods.

Indexed as

Antiviral AgentsFormamidesHumansVirusesVirus ReplicationAntiviral AgentsformamideFormamidesAntiviral activityCo-evolutionComplexityFormamide modelPrebiotic chemistry

Identifiers

PMID40750837
PMCPMC12317059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.