Evidence map›Paper›PMID 40750828›Full record

ArticleCommunications biology2025

The main protease (M

Anna Pagotto, Federico Uliana, Elena Cavedon, Giulia Nordio, Andrea Pierangelini, Laura Acquasaliente, Maria Ludovica Macchia, Massimo Bellanda, Barbara Gatto, Giustina De Silvestro and 5 more

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anna Pagotto *Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.
Federico Uliana *Department of Biology, Institute of Biochemistry, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-8185-6438
Elena CavedonDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.
Giulia NordioDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.ORCID http://orcid.org/0009-0006-0905-7785
Andrea PierangeliniDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.ORCID http://orcid.org/0009-0009-9396-619X
Laura AcquasalienteDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0001-6495-0871
Maria Ludovica MacchiaDept. of Chemical Sciences, University of Padua, Padua, Italy.ORCID http://orcid.org/0009-0001-8986-5718
Massimo BellandaDept. of Chemical Sciences, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0002-8187-0264
Barbara GattoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0001-9465-6913
Giustina De SilvestroDepartment of Transfusion Medicine, University Hospital of Padova, Padua, Italy.
Piero MarsonDepartment of Transfusion Medicine, University Hospital of Padova, Padua, Italy.
Dario GregoriBio-statistic Unit, Department of Cardiovascular Medicine and Public Health, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0001-7906-0580
Paolo SimioniThrombotic and Haemorrhagic Diseases Unit, Department of Medicine, University of Padua, Padua, Italy.
Paola PicottiDepartment of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-4109-3552
Vincenzo De FilippisDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy. vincenzo.defilippis@unipd.it.ORCID http://orcid.org/0000-0001-9775-8894

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions) 101207537Fondazione Cassa di Risparmio di Padova e Rovigo (Foundation Cariparo) 52012
6 · The paper itself

Abstract

Although the connection between COVID-19 and coagulopathy has been clear since the beginning of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain elusive. Available data support that the hyper-coagulant state is sustained by systemic inflammation. Here we show that the SARS-CoV-2 main protease (M

Indexed as

Blood CoagulationCoronavirus 3C ProteasesCOVID-19Factor XIIISARS-CoV-2HumansProteolysisCoronavirus 3C ProteasesFactor XIII

Identifiers

PMID40750828
PMCPMC12316959

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.