Evidence map›Paper›PMID 40750781›Full record

ArticleNature communications2025

Personalized ML-based wearable robot control improves impaired arm function.

James Arnold, Prabhat Pathak, Yichu Jin, David Pont-Esteban, Connor M McCann, Carolin Lehmacher, John P Bonadonna, Tanguy Lewko, Katherine M Burke, Sarah Cavanagh and 6 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

James Arnold *John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Prabhat Pathak *John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Yichu JinJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0009-0000-5167-0950
David Pont-EstebanJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Connor M McCannJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6549-8626
Carolin LehmacherJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
John P BonadonnaJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Tanguy LewkoJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Katherine M BurkeNeurological Clinical Research Institute, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5820-5880
Sarah CavanaghJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0009-0006-3196-5464
Lynn BlaneyCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Kelly RisheCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0009-0008-3676-9512
Tazzy ColeJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Sabrina PaganoniNeurological Clinical Research Institute, Massachusetts General Hospital, Boston, MA, USA.
David LinCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Conor J WalshJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. walsh@seas.harvard.edu.ORCID http://orcid.org/0000-0002-2744-917X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Portable wearable robots offer promise for assisting people with upper limb disabilities. However, movement variability between individuals and trade-offs between supportiveness and transparency complicate robot control during real-world tasks. We address these challenges by first developing a personalized ML intention detection model to decode user's motion intention from IMU and compression sensors. Second, we leverage a physics-based hysteresis model to enhance control transparency and adapt it for practical use in real-world tasks. Third, we combine and integrate these two models into a real-time controller to modulate the assistance level based on the user's intention and kinematic state. Fourth, we evaluate the effectiveness of our control strategy in improving arm function in a multi-day evaluation. For 5 individuals post-stroke and 4 living with ALS wearing a soft shoulder robot, we demonstrate that the controller identifies shoulder movement with 94.2% accuracy from minimal change in the shoulder angles (elevation: 3.4°, depression: 1.7°) and reduces arm-lowering force by 31.9% compared to a baseline controller. Furthermore, the robot improves movement quality by increasing their shoulder elevation/depression (17.5°), elbow (10.6°) and wrist flexion/extension (7.6°) ROMs; reducing trunk compensation (up to 25.4%); and improving hand-path efficiency (up to 53.8%).

Indexed as

ArmRoboticsWearable Electronic DevicesAdultAgedAmyotrophic Lateral SclerosisBiomechanical PhenomenaFemaleHumansMaleMiddle AgedMovementRange of Motion, ArticularShoulderStrokeStroke Rehabilitation

Identifiers

PMID40750781
PMCPMC12317069

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.