ArticleNature communications2025
Peptide-based rigid nanorod-reinforced gelatin methacryloyl hydrogels for osteochondral regeneration and additive manufacturing.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Photoinitiator-free gelatin hydrogel microneedles for acute gouty arthritis treatment.Science advances · 2026Article
- Data-Driven Development of Biomedical Hydrogels for Controlled Drug Delivery: Clinical Applications and Emerging Machine-Learning Approaches.Journal of functional biomaterials · 2026Review
- Hydrogel nanofiber-based 3D cell cultures and organoids.Chemical science · 2026Review
- Antibacterial and Wound-Healing Efficacy of 12-Hydroxylauric Acid-Conjugated Heterochiral Diphenylalanines: Insights From In Vitro and In Vivo Investigations.Chembiochem : a European journal of chemical biology · 2026Article
- Hydrogels: current biomedical applications and future directions.Molecular biomedicine · 2026Review
- Light-assisted 3D bioprinting of tough hydrogels in biomedical applications.Materials today. Bio · 2026Review
- Advanced fabrication protocol of an elastic porous membrane for organ-on-a-chip applications.SLAS technology · 2026Article
- A sequential and synergistic release sacrificial microgels scaffold for endometrial niche reprogramming and fertility restoration.Materials today. Bio · 2026Article
- TiONanomaterials (Basel, Switzerland) · 2026Article
- Engineering a vascularized-osteogenic microenvironment to enhance bone regeneration via a 3D-printed composite scaffold with progressive-release bio-factors.Journal of translational medicine · 2026Article
- Occlusion-activated autonomous piezoelectric implants for adaptive prevention of peri-implantitis.Nature communications · 2026Article
- 3D-printed implantable CAR-macrophages for post-surgery cancer immunotherapy.Journal of nanobiotechnology · 2026Article
- The 3D Printing of Flexible Materials: Technologies, Materials, and Challenges.Materials (Basel, Switzerland) · 2025Review
- Strong living scaffolds for load-bearing musculoskeletal tissue regeneration.Materials today. Bio · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Enhancing the toughness of hydrogels for biomedical applications remains a challenge, as many toughening approaches often sacrifice biocompatibility or in situ applicability, thereby restricting their broader utility in biomedical contexts. Inspired by the intervertebral disk, here, we introduce a biocompatible toughening strategy using peptide-based rigid nanorods (PRNs) as backbone supports within gelatin methacryloyl (GelMA) hydrogels. PRNs are short polymers with exceptional rigidity, capable of covalent cross-linking with GelMA molecules at both ends. Photocuring nanorod-supported GelMA (NSG) molecules yields NSG hydrogels, which demonstrate great improvements in compressive strength (1018%) and toughness (508%) compared to untreated GelMA hydrogels, alongside enhanced structural integrity and fatigue resistance. We further demonstrate that NSG hydrogels are ideal for in situ repair of damaged osteochondral tissues and are highly compatible with additive manufacturing, owing to their good biocompatibility and photocurable properties. This strategy provides a potential pathway for developing highly biocompatible and tough hydrogels, significantly expanding their potential for biomedical applications.
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Registered trials
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