Evidence map›Paper›PMID 40750771›Full record

ArticleNature communications2025

Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord.

Qian Zeng, Yitong Li, Yifei Wu, Jiawei Wu, Kangtai Xu, Yiming Chen, Yunfei Rao, Nan Li, Yuhui Luo, Changyu Jiang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Maladaptive immunity to the microbiota promotes neuronal hyperinnervation and itch via IL-17A.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Central neural circuits underlying itch sensation.Nature reviews. Neuroscience · 2025
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qian Zeng *Department of Medical Neuroscience, School of Medicine; Shenzhen People's Hospital, The First Affiliated Hospital; Southern University of Science and Technology, Shenzhen, Guangdong, China.
Yitong Li *Department of Medical Neuroscience, School of Medicine; Shenzhen People's Hospital, The First Affiliated Hospital; Southern University of Science and Technology, Shenzhen, Guangdong, China.
Yifei Wu *Department of Medical Neuroscience, School of Medicine; Shenzhen People's Hospital, The First Affiliated Hospital; Southern University of Science and Technology, Shenzhen, Guangdong, China.
Jiawei WuDepartment of Medical Neuroscience, School of Medicine; Shenzhen People's Hospital, The First Affiliated Hospital; Southern University of Science and Technology, Shenzhen, Guangdong, China.
Kangtai XuDepartment of Medical Neuroscience, School of Medicine; Shenzhen People's Hospital, The First Affiliated Hospital; Southern University of Science and Technology, Shenzhen, Guangdong, China.
Yiming ChenDepartment of Medical Neuroscience, School of Medicine; Shenzhen People's Hospital, The First Affiliated Hospital; Southern University of Science and Technology, Shenzhen, Guangdong, China.ORCID http://orcid.org/0009-0009-4847-3847
Yunfei RaoDepartment of Medical Neuroscience, School of Medicine; Shenzhen People's Hospital, The First Affiliated Hospital; Southern University of Science and Technology, Shenzhen, Guangdong, China.
Nan LiDepartment of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, The 6th Affiliated Hospital of Shenzhen University Medical School, Shenzhen, Guangdong, China.
Yuhui LuoDepartment of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, The 6th Affiliated Hospital of Shenzhen University Medical School, Shenzhen, Guangdong, China.
Changyu JiangDepartment of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, The 6th Affiliated Hospital of Shenzhen University Medical School, Shenzhen, Guangdong, China. changyujiang@email.szu.edu.cn.ORCID http://orcid.org/0000-0003-4730-8988
Chaoran WuDepartment of Medical Neuroscience, School of Medicine; Shenzhen People's Hospital, The First Affiliated Hospital; Southern University of Science and Technology, Shenzhen, Guangdong, China. wu.chaoran@szhospital.com.ORCID http://orcid.org/0009-0003-5193-7813
Zilong WangDepartment of Medical Neuroscience, School of Medicine; Shenzhen People's Hospital, The First Affiliated Hospital; Southern University of Science and Technology, Shenzhen, Guangdong, China. wangzl6@sustech.edu.cn.ORCID http://orcid.org/0000-0001-7473-0354

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82101297Shenzhen Science and Technology Innovation Commission 20231120133942002 and JCYJ20220818103206013
6 · The paper itself

Abstract

Itch is a common side effect of opioid analgesics. The specific neurons mediating opioid-induced itch are still debated, and the mechanistic neuronal circuits remain elusive. Here, we show that the μ-opioid receptors (MOR) on neuropeptide Y (NPY)

Indexed as

Analgesics, OpioidGastrin-Releasing PeptideNeuronsNeuropeptide YPruritusReceptors, BombesinSpinal CordAnimalsInterneuronsMaleMiceMice, Inbred C57BLMice, KnockoutMorphineReceptors, Neuropeptide YReceptors, Opioid, muAnalgesics, OpioidGastrin-Releasing PeptideMorphineNeuropeptide Yneuropeptide Y-Y1 receptorOprm protein, mouseReceptors, BombesinReceptors, Neuropeptide YReceptors, Opioid, mu

Identifiers

PMID40750771
PMCPMC12317128

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.