Evidence map›Paper›PMID 40750755›Full record

ArticleArchives of pharmacal research2025

9H-carbazole derivatives from a Streptomyces species under potassium iodide stress and their anti-inflammatory properties.

Pengcheng Yan, Yunlong Liu, Jibin Liu, Linmeng Chen, Ning Li, Weiming Zhu

Abstract read
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In one paragraph

Article in Archives of pharmacal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Pengcheng Yan *Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Yunlong Liu *Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Jibin Liu *Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China.
Linmeng ChenKey Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Ning LiBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China. ninglibio@163.com.
Weiming ZhuKey Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. weimingzhu@ouc.edu.cn.ORCID http://orcid.org/0000-0002-7591-3264

Funding

Key Technologies Research and Development Program 2022YFC2804100National Natural Science Foundation of China 82473838
6 · The paper itself

Abstract

By continuously activating silent gene cluster of the marine-derived Streptomyces strain OUCMDZ-5511 under high salt stress, three new iodinated 9H-carbazole derivatives (1-3) and a novel oxazole-fused chlorinated 9H-carbazole derivative (4), along with five previously reported analogues (5-9), were obtained from the cultures grown with 7.5% potassium iodide (KI). The structures of these previously undocumented compounds were elucidated as 4-iodo-3-methoxy-9H-carbazole (1), 4-iodo-3-methoxy-9H-carbazole-6-ol (2), 4-iodo-3-methoxy-9H-carbazole-8-ol (3), and 10-chloro-9-methoxy-6H-oxazolo[5,4-c]carbazole (4), using MS and NMR spectroscopic techniques. Notably, compound 3 demonstrated a more potent anti-inflammatory effect than the positive control in a CuSO

Indexed as

Anti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalCarbazolesInflammationPotassium IodideStreptomycesAnimalsCopper SulfateDose-Response Relationship, DrugMolecular StructureNF-kappa BStructure-Activity RelationshipZebrafishAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalCarbazolesCopper SulfateNF-kappa BPotassium Iodide9H-IodocarbazolesAnti-inflammatory activityCarbazole alkaloidsIodine salt stressMicrobial natural products

Identifiers

PMID40750755

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.