ArticleNature plants2025
Two Melanthiaceae genomes with dramatic size difference provide insights into giant genome evolution and maintenance.
Article in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- A chromosome-level genome assembly of Lycoris radiata reveals the evolutionary origin of Amaryllidaceae alkaloids and elucidates the complete galanthamine biosynthetic pathway.Plant communications · 2026Article
- A near-complete genome assembly of onion resolves its genomic architecture, origin, and evolution.Plant communications · 2026Article
- The Nigella damascena genome provides insights into transposable element-driven genomic gigantism and trait evolution.Nature communications · 2026Article
- Assembly of Silphium interspecific hybrid genomes opens the genus to phylogenomics, ecogenomics, and molecular breeding.Nature communications · 2026Article
- Genome-wide identification and expression analysis of the bHLH gene family in Lilium davidii var. unicolor and its response to abiotic stress.BMC plant biology · 2026Article
- LGD: a comprehensive online database of Liliales based on multi-omics data.Horticulture research · 2026Article
- Identification of genome size and heterozygosity in 510 Jujube (Frontiers in plant science · 2026Article
- Multi-dimensional identification and quality evaluation ofFrontiers in plant science · 2026Article
- Herbgenomics: Unraveling natural product biosynthesis in traditional Chinese medicine.Chinese herbal medicines · 2026Article
- Genome-Wide Identification and Expression Analysis of the AS2/LOB Transcription Factor Family inGenes · 2025Article
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20 authors.
Funding
Abstract
To characterize genome size evolution in the Melanthiaceae family, we sequenced the genomes of Paris polyphylla var. yunnanensis (54.58 Gb/1C) and Veratrum dahuricum (Turcz.) O. Loes. (3.93 Gb/1C). Using a hierarchical bottom-up chromosome assembly strategy, we successfully assembled the five giant chromosomes of P. polyphylla, with the largest chromosome reaching 14.14 Gb. We observed widespread secondary diagonal signals in a Hi-C interaction heat map of P. polyphylla, which suggests a higher-order helical structure (with ~250 Mb per turn) of interphase chromatin. Our genome assemblies reveal that P. polyphylla has not undergone recent whole-genome duplications since its divergence from V. dahuricum. Gene family analysis showed that the five DNA repair pathways are all significantly enriched in the expanded gene families in P. polyphylla. Our results not only report a giant, high-quality plant genome, but also reveal how giant chromosomes evolved and were retained.
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