ReviewNPJ Regenerative medicine2025
From fragment to form: whole-body regeneration in a model urochordate.
Review in NPJ Regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Tissue and organ regeneration are common among aquatic invertebrates, yet these taxa and their potential as model organisms remain underexplored. We present evidence of extensive regenerative capabilities in aquatic invertebrates, highlighting examples of whole-body regeneration (WBR), a peak form of regeneration, where entire organisms regenerate from minute body fragments. Among the many examples of WBR, we focus on botryllid ascidians, an intriguing group of invertebrate chordates that display chordate tissue complexity while demonstrating WBR from small fragments of blood vessels. Centering on WBR in the model species Botrylloides leachi, we outline shared characteristics of WBR across botryllid ascidians including the presence of circulating multipotent stem cells, systemic induction processes, and ensuing competition among regeneration sites, culminating in the restoration of a complete organism. This regeneration mode is distinct from those in mammals and humans. Further research may offer valuable insights into mechanisms by which tissue fragments reinstate new organisms.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.