ArticleNPJ biofilms and microbiomes2025
Infant gut microbiota and SCFAs mediate the association between early-life human milk microbiota and neurodevelopment.
Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bibliometric and visual analysis of gut microbiota research in functional bowel disorders from 2016 to 2025.Frontiers in medicine · 2026Pooled it
- Trial
- Parental microbiome programming of early-life neurodevelopment: multi-niche contributions through the microbiome-gut-brain axis.Gut microbes · 2026Review
- Human milk microbiome as a modulator of the early-life gut-brain axis: mechanisms and translational opportunities for neurodevelopment.Journal of translational medicine · 2026Review
- Investigating the role of baseline gut Akkermansia muciniphila and its co-metabolite palmitoleic acid in BCG vaccine efficacy: a preclinical study.EBioMedicine · 2026Article
- Gestational diabetes mellitus and maternal-infant microbiome axis: mechanistic insights and therapeutic interventions.Journal of translational medicine · 2026Review
- Bioactive-Supplemented Infant Formulas and Early Gut-Immune-Endocrine Development: A Narrative Review.International journal of molecular sciences · 2026Review
- Review
- The maternal gut-fetal brain axis: role of maternal microbial metabolome in early neurodevelopment.Frontiers in nutrition · 2026Review
- Preterm birth alters the gut microbiota, metabolome and health outcomes of twins at 12 months of age.Frontiers in cellular and infection microbiology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Human milk microbiota (HMM) plays a key role in infant gut microbiota (IGM) establishment, however, the influence of the early life HMM in later neurodevelopment remains unclear. In this mother-infant cohort, we investigated HMM development and its impact on IGM-neurodevelopment crosstalk. Breast milk and infant feces were collected on days 0, 7, and 30 for sequencing and SCFAs quantification, while neurodevelopment was assessed via ASQ-3 at 12 months. HMM remained stable during the first month, while IGM fluctuated significantly within the first 7 days. Songbird and mediation analyses revealed strengthening associations between HMM, IGM, and neurodevelopment over time. IGM served as a key mediator linking HMM to neurodevelopment, with SCFAs playing a mediating role in the connection between IGM and neurodevelopment on day 30. Our findings suggest that early-life stable and unique HMM may influence long-term neurodevelopment by dynamically modulating IGM and SCFAs, highlighting a potential strategy to prevent neurodysplasia by monitoring mother-infant microecology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.