Evidence map›Paper›PMID 40750591›Full record

ArticleNPJ vaccines2025

Vaccination-induced neutralizing antibodies in immunocompetent hosts correlate with protection against rickettsiae.

Loka Reddy Velatooru, Jessica Plante, Chen Yi Chu, Garrett Cutchin, Bing Zhu, Nicole Burkhardt, Carsen Roach, Yingzi Cong, Shahid Karim, Yong-Fang Kuo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Loka Reddy VelatooruDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Jessica PlanteDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Chen Yi ChuDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Garrett CutchinDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Bing ZhuDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Nicole BurkhardtDepartment of Entomology, University of Minnesota, St. Paul, MN, USA.
Carsen RoachDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Yingzi CongDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Shahid KarimSchool of Biological, Environmental, and Earth Sciences, University of Southern Mississippi, Hattiesburg, MS, USA.
Yong-Fang KuoDepartment of Biostatistics & Data Science, University of Texas Medical Branch, Galveston, TX, USA.
David H WalkerDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Ulrike MunderlohDepartment of Entomology, University of Minnesota, St. Paul, MN, USA.
Rong FangDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA. rofang@utmb.edu.

Funding

Rational development of a vaccine against tick-borne rickettsiosesR01AI163857 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI FANG, RONG MEGAN · 2022 to 2025
$3.2M
Identification of diagnostic biomarkers for flea-borne typhusR21AI183177 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Rong Megan Fang · 2025 to 2026
$433k
National Institute of Allergy and Infectious Diseases (NIAID) / National institute of Health (NIH) R01 AI163857, R21AI183177 and R21AI151904 to R.F.NIAID NIH HHS R01 AI163857NIAID NIH HHS R21 AI183177
6 · The paper itself

Abstract

We previously demonstrated that a single-dose immunization with a live-attenuated Rickettsia parkeri mutant 3A2 confers complete protection against murine spotted fever rickettsioses. In this study, we investigated whether vaccination-elicited serum antibodies serve as immune correlates of protection against rickettsiae. Immunization of immunocompetent C3H/HeN mice with 3A2 induced a robust and durable level of IgG antibody response, predominantly comprising IgG2a, IgG3, and IgG2b subclasses, and was associated with a significant expansion of CD19

Identifiers

PMID40750591
PMCPMC12316887

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.