Evidence map›Paper›PMID 40750586›Full record

ArticleTranslational psychiatry2025

Machine learning in psychiatric health records: A gold standard approach to trauma annotation.

Eben Holderness, Bruce Atwood, Marc Verhagen, Ann K Shinn, Philip Cawkwell, Hudson Cerruti, James Pustejovsky, Mei-Hua Hall

Abstract read
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Eben HoldernessPsychosis Neurobiology Laboratory, McLean Hospital, Belmont, MA, USA.
Bruce AtwoodPsychosis Neurobiology Laboratory, McLean Hospital, Belmont, MA, USA.
Marc VerhagenDepartment of Computer Science, Brandeis University, Waltham, MA, USA.
Ann K ShinnSchizophrenia and Bipolar Disorder Research Program, McLean Hospital, Belmont, MA, USA.
Philip CawkwellPsychosis Neurobiology Laboratory, McLean Hospital, Belmont, MA, USA.
Hudson CerrutiUniversity of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
James PustejovskyDepartment of Computer Science, Brandeis University, Waltham, MA, USA.
Mei-Hua HallPsychosis Neurobiology Laboratory, McLean Hospital, Belmont, MA, USA. mhall@mclean.harvard.edu.ORCID http://orcid.org/0000-0002-4558-7023

Funding

Identification of Trauma-related Features in EHR Data for Patients with Psychosis and Mood DisordersR21MH125076 · NIMH · MCLEAN HOSPITAL · PI HALL, MEI-HUA, PUSTEJOVSKY, JAMES · 2021 to 2022
$466k
NIMH NIH HHS R21 MH125076U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH125076
6 · The paper itself

Abstract

Psychiatric electronic health records present unique challenges for machine learning due to their unstructured, complex, and variable nature. This study aimed to create a gold standard dataset by identifying a cohort of patients with psychotic disorders and posttraumatic stress disorder, (PTSD), developing clinically-informed guidelines for annotating traumatic events in their health records and to create a gold standard publicly available dataset, and demonstrating the dataset's suitability for training machine learning models to detect indicators of symptoms, substance use, and trauma in new records. We compiled a representative corpus of 200 narrative heavy health records (470,489 tokens) from a centralized database and developed a detailed annotation scheme with a team of clinical experts and computational linguistics. Clinicians annotated the corpus for trauma-related events and relevant clinical information with high inter-annotator agreement (0.715 for entity/span tags and 0.874 for attributes). Additionally, machine learning models were developed to demonstrate practical viability of the gold standard corpus for machine learning applications, achieving a micro F1 score of 0.76 and 0.82 for spans and attributes respectively, indicative of their predictive reliability. This study established the first gold-standard dataset for the complex task of labelling traumatic features in psychiatric health records. High inter-annotator agreement and model performance illustrate its utility in advancing the application of machine learning in psychiatric healthcare in order to better understand disease heterogeneity and treatment implications.

Indexed as

Electronic Health RecordsMachine LearningPsychotic DisordersStress Disorders, Post-TraumaticFemaleHumansMale

Identifiers

PMID40750586
PMCPMC12317041

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.