Evidence map›Paper›PMID 40750466›Full record

Observational studyBritish journal of anaesthesia2025

Robotic process automation to identify patients at high risk for perioperative myocardial infarction or injury: a prospective, blinded, paired reader-controlled single-centre study.

Koray Durak, Katrin Burri-Winkler, Gabrielle Huré, Ivo Strebel, Julia Reinhardt, Vanessa Thommen, Mirjam Pargger, Noemi Glarner, Fisnik Haziri, Esther Seeberger and 11 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02573532 (Basel Incidence, Patient Characteristics, Outcome and Possible Strategies to Improve Outcome of Perioperative Myocardial Injury After Non-cardiac Surgery), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02573532 active not recruitingnot on this map

Basel Incidence, Patient Characteristics, Outcome and Possible Strategies to Improve Outcome of Perioperative Myocardial Injury After Non-cardiac Surgery: 1-Year Follow-up

TypeobservationalSponsorUniversity Hospital, Basel, SwitzerlandRan2015 to 2027Enrolled19,645ConditionsPerioperative Myocardial Injury
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Koray DurakDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Katrin Burri-WinklerDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland; Department of Anaesthesia, University Hospital Basel, University of Basel, Basel, Switzerland.
Gabrielle HuréDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Ivo StrebelDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Julia ReinhardtDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Vanessa ThommenDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Mirjam ParggerDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Noemi GlarnerDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Fisnik HaziriDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Esther SeebergerDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Nadine DoyleDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Daniel BolligerDepartment of Anaesthesia, University Hospital Basel, University of Basel, Basel, Switzerland.
Luzius A SteinerDepartment of Anaesthesia, University Hospital Basel, University of Basel, Basel, Switzerland; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Edin MujagicDepartment of Vascular Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Didier LardinoisDepartment of Thoracic Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Stefan SchärenDepartment of Spinal Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Andreas MuellerDepartment of Orthopedics and Trauma Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Felix MahfoudDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Danielle Menosi GualandroDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Christian PuelacherDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland; Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: christian.puelacher@i-med.ac.at.
Christian MuellerDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland. Electronic address: christian.mueller@usb.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough current guidelines recommend active surveillance for perioperative myocardial infarction, injury, or both in high-risk patients, implementation remains limited in most institutions worldwide because of a lack of resources.

methodsWe hypothesised that robotic process automation (RPA), a software technology that enables virtual bots to replicate human tasks within digital systems, could accurately replace experienced clinical staff. Manual screening by experienced clinical staff and RPA screening were carried out simultaneously and blinded to identify high-risk patients eligible for active surveillance for myocardial infarction/injury, according to predefined screening criteria. Discrepant identification was reviewed by an independent clinician blinded to the origin of the identification, generating a reference standard classification of paired reader-controlled patients to investigate the primary diagnostic endpoint: relative true positive fraction.

resultsIn 660 participants (median age 60 yr, interquartile range 42-73 yr, 54.8% female), 77/660 (12%) were eligible for active surveillance for perioperative myocardial infarction or injury according to the reference standard classification. RPA screening achieved 75 (97%) true positive identifications, compared with 63 (82%) identified from manual screening (relative true positive fraction: 1.19, 95% confidence interval 1.08-1.32, P=0.004). The number needed to screen to identify one additional true positive using RPA screening was 6. RPA screening had a sensitivity of 0.97 (0.91-0.99), compared with 0.82 (0.72-0.89) for. Both approaches had high specificity (RPA screening: 0.98 [0.97-0.99], compared with manual screening: 1.0 [0.99-1.00]). The estimated annual cost of RPA screening was 81% lower compared with manual screening.

conclusionsRPA screening was superior to standard-of-care manual screening by experienced clinical staff in identifying patients at high risk for perioperative myocardial infarction or injury. CLINICAL

trial registrationNCT02573532.

Indexed as

Myocardial InfarctionPostoperative ComplicationsRoboticsRobotic Surgical ProceduresAdultAgedAutomationFemaleHumansMaleMiddle AgedProspective StudiesRisk AssessmentSingle-Blind Methodactive surveillancemyocardial injury after noncardiac surgeryperioperative careperioperative myocardial infarctionperioperative myocardial injuryrobotic process automation

Identifiers

PMID40750466
PMCPMC12597386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.