Evidence map›Paper›PMID 40750357›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

SRC Kinase Isoforms Regulate mRNA Splicing during Neural Development.

Alastair R Pizzey, Laura C West, Samuel J Elberfeld, Philip A Lewis, Hannah Walker, Laura Cowell, Katherine Newling, Adam Dowle, Gareth J O Evans, Harry V Isaacs

Abstract read
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In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alastair R PizzeyDepartment of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, United Kingdom.ORCID 0000-0002-9998-5190
Laura C WestDepartment of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, United Kingdom.
Samuel J ElberfeldDepartment of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, United Kingdom.
Philip A LewisDepartment of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, United Kingdom.
Hannah WalkerDepartment of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, United Kingdom.
Laura CowellDepartment of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, United Kingdom.
Katherine NewlingDepartment of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, United Kingdom.
Adam DowleDepartment of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, United Kingdom.
Gareth J O EvansDepartment of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, United Kingdom harry.isaacs@york.ac.uk gareth.evans@york.ac.uk.ORCID 0000-0003-2573-7001
Harry V IsaacsDepartment of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, United Kingdom harry.isaacs@york.ac.uk gareth.evans@york.ac.uk.ORCID 0000-0001-7825-536X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternative mRNA splicing generates transcriptomic diversity to direct tissue-specific functions. There is a high level of alternative splicing in the brain during embryonic development, but the master regulators of this process are poorly understood. One key splicing event in neuronal differentiation is the inclusion of a microexon in the SH3 domain of the ubiquitous tyrosine kinase, C-SRC, to yield the constitutively active, neural-specific N1-SRC kinase. We previously demonstrated that specific inhibition of N1-SRC in developing

Indexed as

Alternative SplicingNeurogenesisNeuronsRNA, MessengerRNA Splicingsrc-Family KinasesAnimalsGene Expression Regulation, DevelopmentalProtein Isoformssrc Homology DomainsXenopus laevisProtein IsoformsRNA, Messengersrc-Family KinasesneurogenesisphosphorylationSRCtyrosine kinaseXenopus

Identifiers

PMID40750357
PMCPMC12369926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.