ArticleBMJ open2025
Paediatric liver transplantation-improving health care through needs assessment, screening and interventions: protocol for a mixed-methods study.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionPaediatric liver transplantation (pLTX) is a life-saving procedure that can improve the quality of life and physical activity of children. However, the condition after pLTX presents a number of challenges for the children and their families. There is a lack of data on specific needs and utilisation of healthcare services after pLTX. Also, symptoms of mental health problems in children often remain unrecognised. Hence, the overall aim of this project is to investigate the situation of children and their families after pLTX and to develop and implement a screening tool and information material for children and their families. METHODS AND ANALYSIS: The project will use a multimethod approach to investigate the objectives of the three study arms. In study arm 1, recommendations for comprehensive and needs-based psychosocial care will be derived from quantitative data (questionnaires) and qualitative data (interviews with children after liver transplantation, their caregivers, siblings and healthcare professionals (HCPs)). The aims are to collect quantitative data from n=125 cases and to conduct n=10-12 interviews per group. In study arm 2, a distress screening will be developed based on a literature search and n=10-20 interviews with families and HCPs. The screening will subsequently be piloted in two clinics for a period of 6 months. Finally, in study arm 3, findings from study arms 1 and 2 will be used to develop informational materials for families affected. The study will be conducted at the Department of Medical Psychology and the Department of Pediatrics of the University Medical Center Hamburg-Eppendorf in Germany in cooperation with the transplant centre of the University Children's Hospital Essen. ETHICS AND DISSEMINATION: The study has been approved by the Local Psychological Ethics Committee of the Center for Psychosocial Medicine of the University Medical Center Hamburg-Eppendorf (LPEK-0618) and the Ethics Committee of the University Medicine Duisburg/Essen (23-11416-BO). The findings of the study will be presented at national and international conferences and will be published in peer-reviewed scientific journals. Written informed consent will be obtained from all participants. REGISTRATION: Open Science Framework (OSF): https://osf.io/rdw4b.
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