Pathologic Evidence of Granulomatosis With Polyangiitis as a Cause of Atrioventricular Block.

Naoki Watanabe, Kenji Harada, Shigeo Kawai, Hisaya Kobayashi, Kazuomi Kario

Abstract readCase Reports

In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Extensive Cardiac Involvement in ANCA-Associated Vasculitis Presenting With Severe Aortic Regurgitation and Atrioventricular Block.JACC. Case reports · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Naoki WatanabeDivision of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan; Department of Cardiology, Tochigi Medical Center Shimotsuga, Shimotsuke, Tochigi, Japan.

Kenji HaradaDivision of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan. Electronic address: haradak@jichi.ac.jp.

Shigeo KawaiDepartment of Pathology, Tochigi Medical Center Shimotsuga, Shimotsuke, Tochigi, Japan.

Hisaya KobayashiDivision of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan; Department of Cardiology, Tochigi Medical Center Shimotsuga, Shimotsuke, Tochigi, Japan.

Kazuomi KarioDivision of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrioventricular block (AVB) is a rare manifestation of granulomatosis with polyangiitis (GPA), and the underlying pathologic relationship between GPA and AVB remains poorly understood. CASE SUMMARY: We present the case of a 71-year-old woman who developed complete AVB and had a history of microscopic polyangiitis. Despite the absence of clinical signs indicative of GPA relapse throughout her lifetime, postmortem examination revealed microgranulomas and multinucleated giant cells within the atrioventricular node. DISCUSSION: This case provides pathologic evidence that GPA can lead to complete heart block as an initial clinical manifestation. TAKE-HOME MESSAGES: GPA-associated AVB can improve with immunosuppressive therapy. GPA should be considered in the differential diagnosis of AVB of unknown etiology.

Indexed as

atrioventricular blockgranulomatosis with polyangiitispathology

Identifiers

PMID40750159

DOI10.1016/j.jaccas.2025.104414

PMCPMC12441480

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