Evidence map›Paper›PMID 40750150›Full record

ArticleJACC. Case reports2025

Radial Approach Renal Denervation: A First-in-Man Case With the 4-F TIVUS Catheter.

Ortal Tuvali, Alex Blatt, Gabby Elbaz-Greener, Iddo Z Ben-Dov, Christian Spaulding, James P Zidar, Ajay J Kirtane, Michael Jonas

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Renal Denervation in Cardiovascular Diseases: Mechanisms, Evidence, and Expanding Applications.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ortal TuvaliThe Heart Institute, Kaplan Medical Center, Hebrew University, Jerusalem, Israel. Electronic address: Ortalhagege@gmail.com.
Alex BlattThe Heart Institute, Kaplan Medical Center, Hebrew University, Jerusalem, Israel.
Gabby Elbaz-GreenerDepartment of Cardiology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Iddo Z Ben-DovDepartment of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel.
Christian SpauldingDepartment of Cardiology, European Hospital Georges Pompidou, Assistance Publique Hôpitaux de Paris and Paris Cité University, Paris, France.
James P ZidarRex Healthcare, University of North Carolina (UNC), JPZ, Raleigh, North Carolina, USA.
Ajay J KirtaneCardiovascular Research Foundation, New York, New York, USA; Columbia University Irving Medical Center/New York-Presbyterian Hospital, New York, New York, USA.
Michael JonasThe Heart Institute, Kaplan Medical Center, Hebrew University, Jerusalem, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRenal denervation (RDN) is an effective procedure for the treatment of uncontrolled hypertension, typically performed via the femoral approach. Although RDN is generally safe, vascular complications remain the most frequent adverse events. CASE SUMMARY: A 57-year-old man with resistant hypertension was enrolled in the Renal Denervation Using Ultrasonic Catheter EmitteD Energy Study (REDUCED 1) clinical study. He underwent bilateral RDN using a novel 4-F ultrasound-based catheter via left radial arterial access. The procedure was uneventful, and at 3-month follow-up, ambulatory and office blood pressure showed marked reductions. DISCUSSION: This first-in-human case supports the feasibility and safety of transradial RDN using a dedicated 4-F ultrasound catheter. The radial approach may reduce access-site complications and enable same-day discharge. Future studies are needed to confirm the benefits of this system. TAKE-HOME MESSAGE: Transradial RDN using a novel 4-F ultrasound catheter is safe, feasible, and may offer procedural and patient-care advantages over femoral access.

Indexed as

case reporthypertensionradial approachrenal denervationultrasound ablationvascular access

Identifiers

PMID40750150
PMCPMC12441550

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.