ArticleContemporary clinical trials2025
Theory-based physical activity behavior change intervention in people newly diagnosed with multiple sclerosis: Study protocol for a pilot randomized controlled trial.
Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06355804 (Lifestyle Physical Activity Intervention for Persons Newly Diagnosed With Multiple Sclerosis), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lifestyle Physical Activity Intervention for Persons Newly Diagnosed With Multiple Sclerosis
Who cites it
1 citing paper in PubMed.
- Results of a pilot randomized controlled trial of a COM-B-based physical activity behavior-change intervention in people newly diagnosed with multiple sclerosis.Multiple sclerosis and related disorders · 2026Trial
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Authors and funding
2 authors.
Funding
Abstract
backgroundPhysical activity (PA) is strongly recommended for people newly diagnosed with multiple sclerosis (MS). Nevertheless, this MS sub-population is physically inactive, and this disease stage might require unique interventions for promoting PA. PURPOSE: This proposed pilot randomized controlled trial (RCT) examines the effects of a remote-delivered, theory-based behavior change intervention for promoting PA in people newly diagnosed with MS. METHODS/
designThe intervention was developed using a comprehensive approach guided by the Capability-Opportunity-Motivation-Behavior (COMB) Model and the Behavior Change Wheel (BCW). This two-armed RCT (NCT06355804) will enroll 50 people diagnosed with MS within the past two years. Participants will then be randomly assigned, using computer-generated random numbers with allocation concealment, into either the PA intervention or waitlist control (WLC) conditions. Participants randomized into the PA intervention condition will receive the intervention following the baseline assessment, whereas participants in WLC condition will receive the intervention after the follow-up assessment (i.e., after 16 weeks). The primary outcomes of interest include device-measured (light PA [LPA], moderate-to-vigorous PA [MVPA], step counts) and self-reported (i.e., Godin Leisure-Time Exercise Questionnaire and International Physical Activity Questionnaire) PA. Secondary outcomes include fatigue, depression, anxiety, and health-related quality of life (HRQOL). Data will be analyzed with an intent-to-treat approach, using 2 (condition) by 2 (time) mixed-effects ANOVA with effect size estimates of eta-squared (η DISCUSSION: The findings will inform a full-powered RCT of the intervention for promoting immediate and sustained changes in lifestyle, PA, health outcomes, and HRQOL in people newly diagnosed with MS.
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