Trial reportThe Journal of nutrition2025
The Association of Gut Microbiota With TRPM7 Genotype, Colorectal Polyps, and Magnesium.
Trial report in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01105169 (Personalized Prevention of Colorectal Cancer Trial), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Personalized Prevention of Colorectal Cancer Trial (PPCCT)
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundWe previously reported that individuals with the transient receptor potential melastatin 7 (TRPM7) GA/AA genotype and consumed diets high in Ca:Mg ratio had increased risk of colorectal polyps.
objectivesThe aim was to identify whether the gut microbiota plays a role in the association of TRPM7 genotype, Ca:Mg intake ratio, and risk of colorectal polyps.
methodsWe analyzed the gut microbiota of 240 participants in a double-blind 2 × 2 factorial (TRPM7 genotype and Ca:Mg intake ratios) randomized trial by sequencing the stool, rectal swab, and rectal mucosa tissue samples of each participant.
resultsThe gut microbiota of participants with the GA genotype significantly differed from those with the GG genotype in all 3 sample types, with an altered abundance of Prevotella and Bacteroides in swab samples. Prevotella in rectal mucosa and Bacteroides in swab were associated with an increased risk of metachronous colorectal polyps. Optimizing high-diet Ca:Mg ratios to 2.3 through Mg supplementation resulted in a reduced abundance of Prevotella in rectal swabs and Bacteroides in stool samples. We identified multiple microbes in all 3 sample types linked to risk of metachronous colorectal polyps.
conclusionsOur findings indicate that the gut microbiota in stool, rectal swab, and mucosa are associated with risk of metachronous colorectal polyps, and diet changes could modify the abundance of TRPM7-related microbes. This study was registered at clinicaltrials.gov as NCT01105169 (https://clinicaltrials.gov/study/NCT01105169).
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