Evidence map›Paper›PMID 40749789›Full record

ArticleJournal of advanced research2026

Enhanced tuberculosis control via leveraging dendritic cell-mediated Th1 responses in preventive and immunotherapeutic vaccine strategies.

Hongmin Kim, Jong-Seok Kim, Kee Woong Kwon, Woo Sik Kim, Minchul Park, Sang-Jun Ha, Sangwon Choi, Jiseon Kim, Sung Jae Shin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongmin KimDepartment of Microbiology, Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, South Korea.
Jong-Seok KimDepartment of Microbiology, Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, South Korea; Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, South Korea.
Kee Woong KwonDepartment of Microbiology, Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, South Korea; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, South Korea.
Woo Sik KimDepartment of Microbiology, Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, South Korea; Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeollabuk-do, South Korea.
Minchul ParkDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea; Brain Korea 21(BK21) Four program, Yonsei Education & Research Center for Biosystems, Yonsei University, Seoul, South Korea.
Sang-Jun HaDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea; Brain Korea 21(BK21) Four program, Yonsei Education & Research Center for Biosystems, Yonsei University, Seoul, South Korea.
Sangwon ChoiDepartment of Microbiology, Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, South Korea; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Jiseon KimDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Sung Jae ShinDepartment of Microbiology, Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, South Korea; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: sjshin@yuhs.ac.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInsufficient vaccine efficacy of the Bacillus Calmette-Guérin (BCG) and long, expensive tuberculosis (TB) treatments highlight the need for better TB control measures.

methodsThis study evaluated whether the adoptive transfer of dendritic cell (DC)-based vaccines pulsed with culture filtrate antigens (CFA) of Mycobacterium tuberculosis (Mtb) could enhance BCG efficacy and support anti-TB drug therapy.

resultsIn BCG-vaccinated mice, adoptive transfer of CFA-pulsed DCs promoted swift T cell recruitment to the lung parenchyma, reducing bacterial load within 1 week post-infection, promoting the generation of tissue-resident T cells and expansion of CD4

conclusionsDC-based prophylactic and immunotherapeutic vaccine strategies enhance protective immunity during BCG vaccination and chemotherapy, offering new insights into TB control strategies.

Indexed as

BCG VaccineDendritic CellsTh1 CellsTuberculosisTuberculosis VaccinesAnimalsCD4-Positive T-LymphocytesDisease Models, AnimalFemaleMiceMice, Inbred C57BLMycobacterium tuberculosisBCG VaccineTuberculosis VaccinesBCGBooster vaccineDC-based immunotherapyMultifunctional T cellReactivationTuberculosis

Identifiers

PMID40749789
PMCPMC13131435

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.