ArticleEuropean journal of dentistry2026
Blood Vessel, VEGF, and FGF Expression in Traumatic Ulcer Healing of Wister Rats after Application of Chitosan-Aloe vera Gel.
Article in European journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Advancement in nanocarrier-mediated delivery of herbal bioactives: from bench to beside.Natural products and bioprospecting · 2025Review
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Authors and funding
6 authors.
Funding
Abstract
Objectives: The purpose of this study was to analyze the application of chitosan (CH)- Materials and Methods: Chitosan powder with deacetylation degree of 93% dissolved in 2% acetic acid, neutralized with NaOH solution, and combined with AV gel. Traumatic ulcers were made with a 4-mm diameter along the lower labial mucosa of Wistar rats using a heated burnisher. Negative control group (KA) was treated with placebo, positive control group (KB) using 0.2% hyaluronic acid, treatment group using chitosan (CH) gel (PA) and AV gel (PB), and group using combination CH-AV gel (PC). The blood vessel numbers were analyzed with hematoxylin eosin staining and the expression of VEGF and FGF were analyzed using immunohistochemistry on days 3 and 7. Statistical Analysis: One-way analysis of variance was conducted to analyze the difference between groups and the Tukey honestly significant difference multiple comparisons test was used to analyze different pairs of groups ( Results: Blood vessels, VEGF, and FGF expression were higher in the treatment group using combination CH-AV gel on days 3 and 7 compared with the control group and treatment group using CH or AV gel ( Conclusion: The application of CH-AV gel increased the number of blood vessels, VEGF, and FGF expression in traumatic ulcer healing of Wistar rats.
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Registered trials
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