Evidence map›Paper›PMID 40749664›Full record

ArticleImmunity2025

Innate-like memory T cells rapidly emerge in humans after gene therapy for SCID-X1.

Anoop Babu Vasandan, Hossam A Abdelsamed, Shannon K Boi, Grace Ward, Shanta Alli, Tian Mi, Xin Lan, Xusheng Zhang, Morton J Cowan, Jennifer M Puck and 7 more

Abstract read
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anoop Babu VasandanDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hossam A AbdelsamedDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, USA; Immunology Center of Georgia (IMMCG), Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address: habdelsamed@augusta.edu.
Shannon K BoiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Grace WardDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Shanta AlliDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Tian MiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Xin LanDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
Xusheng ZhangDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Morton J CowanDepartment of Pediatrics, Division of Pediatric Allergy, Immunology and Blood and Marrow Transplantation, University of California, San Francisco and UCSF Benioff Children's Hospital, San Francisco, CA 94158, USA.
Jennifer M PuckDepartment of Pediatrics, Division of Pediatric Allergy, Immunology and Blood and Marrow Transplantation, University of California, San Francisco and UCSF Benioff Children's Hospital, San Francisco, CA 94158, USA.
Aleksandra PetrovicDepartment of Pediatrics, Seattle Children's Research Institute, University of Washington School of Medicine, Seattle, WA, USA.
David RawlingsDepartment of Pediatrics, Seattle Children's Research Institute, University of Washington School of Medicine, Seattle, WA, USA.
Albert ZhouExperimental Cellular Therapeutics Laboratory, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ewelina MamcarzDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.
Stephen GottschalkDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.
Caitlin C ZebleyDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: caitlin.zebley@stjude.org.
Ben YoungbloodDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: benjamin.youngblood@stjude.org.

Funding

VIROSOME/PROTEOLIPOSOME MEDIATED GENE TRANSFERP01HL053749 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEISS, MITCHELL J · 1994 to 2022
$43.6M
Training of Clinical Investigators in Primary Immune DeficienciesU54AI082973 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALECH, HARRY · 2009 to 2023
$23.3M
Inherited T cell defects: Diagnosis, Mechanisms and TreatmentsP01AI138962 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PUCK, JENNIFER M. · 2020 to 2024
$11.3M
EPIGENETIC REPROGRAMMING OF T CELL EXHAUSTION TO ENHANCE TUMOR IMMUNOTHERAPYR01CA237311 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Benjamin Alan Youngblood · 2020 to 2026
$2.9M
Epigenetic Regulation of T-cell Exhaustion During Treated Chronic HIV InfectionR01AI114442 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YOUNGBLOOD, BENJAMIN ALAN · 2015 to 2019
$2.1M
Decoding the epigenetic landscape that delineates T cell homeostatic proliferation from uncontrolled growth”K08CA279926 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Caitlin Zebley · 2023 to 2026
$791k
Investigating mechanisms underscoring dichotomous T cell responses between medulloblastoma subgroupsF32CA250155 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI BOI, SHANNON · 2021 to 2021
$48k
NCI NIH HHS F32 CA250155NCI NIH HHS K08 CA279926NCI NIH HHS R01 CA237311NHLBI NIH HHS P01 HL053749NIAID NIH HHS P01 AI138962NIAID NIH HHS R01 AI114442NIAID NIH HHS U54 AI082973
6 · The paper itself

Abstract

Virtual memory T cells, possessing features of innate immune cells, represent a developmental continuum between innate and adaptive immunity. Here, we describe the genesis of virtual memory T cells during early human life. A longitudinal analysis of peripheral T cells after gene therapy for X-linked severe combined immunodeficiency (SCID-X1) in infants revealed an early enrichment of innate-like memory CD8

Indexed as

CD8-Positive T-LymphocytesGenetic TherapyImmunity, InnateImmunologic MemoryMemory T CellsX-Linked Combined Immunodeficiency DiseasesDNA MethylationEpigenesis, GeneticHumansInfantInterferon-gammaMaleNK Cell Lectin-Like Receptor Subfamily CReceptors, Antigen, T-CellInterferon-gammaNK Cell Lectin-Like Receptor Subfamily CReceptors, Antigen, T-Cellhuman immune developmentinnate-memory T cellsvirtual memory T cells

Identifiers

PMID40749664
PMCPMC12321219

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.