ArticleMultiple sclerosis and related disorders2025
Physical activity is associated with fatigue in persons newly diagnosed with multiple sclerosis.
Article in Multiple sclerosis and related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundFatigue is prevalent, debilitating, and poorly managed in multiple sclerosis (MS), particularly in the early stages. To date, the association between physical activity (PA) and fatigue has not been examined in persons newly diagnosed with MS (PNDwMS), yet this could inform fatigue management in early MS. PURPOSE: This study consists of a secondary data analysis that examined the association between PA and sedentary time and fatigue in PNDwMS. MATERIALS AND
methodsParticipants diagnosed with MS for less than two years (n = 47) wore a waist-worn ActiGraph GT3X+ accelerometer for 7 days to measure time spent (minutes/day) in moderate-to-vigorous PA (MVPA), light PA (LPA), sedentary time (ST), and steps/day. Participants further completed the Fatigue Severity Scale (FSS). We examined the relationships between PA outcomes and FSS scores using bivariate correlations. We performed stepwise multiple linear regression analysis of FSS scores on PA outcomes, controlling for disability status assessed by the Patient Determined Disease Steps (PDDS).
resultsBivariate analyses demonstrated significant correlations between LPA (r = -0.42), ST (r = 0.33), and steps/day (r = -0.35) with FSS. The regression analysis indicated that LPA was associated with FSS (β = -0.42, R
conclusionsOur results indicated that LPA was significantly and negatively associated with fatigue, even after controlling for PDDS. The finding highlights the opportunity for developing behavioral interventions targeting LPA for managing fatigue among PNDwMS.
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