Evidence map›Paper›PMID 40749619›Full record

ArticleStem cell research2025

Generation of induced pluripotent stem cells from 8 neurotypical individuals with elevated genetic risk for schizophrenia.

Sangho S Myung, Srinidhi Rao Sripathy, Brady J Maher

Abstract read
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In one paragraph

Article in Stem cell research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sangho S MyungLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Srinidhi Rao SripathyLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Brady J MaherLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: brady.maher@libd.org.

Funding

Biochemistry, Cellular and Molecular Biology Program: JHU BioGREAT (Biomedical Graduate REsiliency & Adaptability Training)T32GM144272 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Takanari Inoue · 2022 to 2026
$5.4M
Understanding Schizophrenia Risk Mechanisms Via Multimodal Analysis of Patient-derived Neurons and 3D Cortical Organoids and Correlation with Clinical and Cognitive PhenotypesR01MH134828 · NIMH · LIEBER INSTITUTE, INC. · PI MAHER, BRADY J, STRAUB, RICHARD ERIC · 2024 to 2025
$1.8M
Modeling schizophrenia with patient-specific mutations in GRIN2A and SP4R21MH132035 · NIMH · LIEBER INSTITUTE, INC. · PI MAHER, BRADY J · 2023 to 2023
$496k
NIGMS NIH HHS T32 GM144272NIMH NIH HHS R01 MH134828NIMH NIH HHS R21 MH132035
6 · The paper itself

Abstract

Schizophrenia (SCZ) is a common and debilitating mental illness characterized by positive and negative symptoms, and impaired cognition. Genome-wide association studies (GWAS) have identified hundreds of genomic regions containing SCZ risk variants. For each individual, a polygenic risk score (PRS) can be derived, which is a metric of genetic susceptibility for SCZ. Here, we report the generation of human induced pluripotent stem cells (hiPSCs) from 8 neurotypical individuals with elevated PRS. These hiPSC lines will be useful to study common variant risk for SCZ and for the generation of isogenic lines containing rare variants associated with SCZ risk.

Indexed as

Genetic Predisposition to DiseaseInduced Pluripotent Stem CellsSchizophreniaAdultFemaleGenome-Wide Association StudyHumansMaleInduced Pluripotent Stem Cells (iPSCs)Polygenic Risk Score (PRS)Schizophrenia (SCZ)

Identifiers

PMID40749619
PMCPMC12490714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.