Evidence map›Paper›PMID 40749418›Full record

ArticlePatient education and counseling2025

"To reach the new generation… TikTok:" Applying behavioral economics to adolescent and young adult HIV pre-exposure prophylaxis education.

Carly E Guss, Brittany Gluskin, Danielle DeMaio, Lauren Wisk, Douglas Krakower

Abstract read
In one paragraph

Article in Patient education and counseling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carly E GussBoston Children's Hospital, Division of Adolescent/Young Adult Medicine, Boston, USA; Havard Medical School, Boston, USA. Electronic address: carly.guss@childrens.harvard.edu.
Brittany GluskinBoston Children's Hospital, Division of Adolescent/Young Adult Medicine, Boston, USA.
Danielle DeMaioBoston Children's Hospital, Division of Adolescent/Young Adult Medicine, Boston, USA.
Lauren WiskDivision of General Internal Medicine & Health Services Research, David Geffen School of Medicine at UCLA, Department of Health Policy and Management, UCLA Fielding School of Public Health, UCLA Fielding School of Public Health, Los Angeles, USA.
Douglas KrakowerHavard Medical School, Boston, USA; Fenway Health, Boston, USA; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, USA.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
NIAID NIH HHS P30 AI060354
6 · The paper itself

Abstract

objectivesTo investigate how adolescents and young adults (AYA) would respond to the framing of health messages for HIV pre-exposure prophylaxis (PrEP) using principles of psychology and economics (behavioral economics). Our hypothesis was that gain-frame messaging (focused on benefits) would be better received than loss-frame messaging (focused on risks).

methodsFocus groups were held to determine AYA preferences for messaging around PrEP to design a social media video. Two videos were developed using either gain-frame (emphasized positive effects of PrEP) or loss-frame messaging (emphasized negative consequences of non-use). Thirty AYA were shown the videos and interviewed about their impressions, message framing preferences, and impact.

resultsInterviews were held May - October 2023. Participants ranged in age from 15 to 25 years (mean 21.5 years) and the majority identified as White (70.0 %). Most (80.0 %) identified as cisgender. A third (33.3 %) had ever tested for HIV, none had an HIV diagnosis, and 36.7 % did not feel that PrEP applied to them personally. Thematic findings included: generally positive views of PrEP, AYA would like to see the video in a doctor's office as this would make it more trustworthy (20 %), and the video would lead them to do additional research. Gain-framed messaging was preferred over the loss-framed video messaging (53.3 %). PrEP efficacy was the most important medical fact presented. AYA disliked advertisement-like or "staged" video elements and favored genuineness and relatability.

conclusionAYA preferred gain-framed over loss-frame PrEP messaging, and information on PrEP efficacy delivered by authentic messengers is likely to resonate. Our study generalizability may be limited due to a primarily cisgender and White sample. These findings offer novel insights into AYA perspectives around PrEP messaging for brief videos that could be disseminated through social media for PrEP education. PRACTICE IMPLICATIONS: Health care professionals should consider using social media and gain-framed messages for health education.

Indexed as

Economics, BehavioralHealth EducationHIV InfectionsPre-Exposure ProphylaxisAdolescentAdultFemaleFocus GroupsHealth Knowledge, Attitudes, PracticeHumansMaleSocial MediaVideo RecordingYoung AdultAdolescentBehavioral economicsHIV pre-exposure prophylaxisSocial mediayoung adultYouth health education

Identifiers

PMID40749418
PMCPMC12334175

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.