Evidence map›Paper›PMID 40749303›Full record

ArticleSchizophrenia research2025

Environmental deprivation is associated with reward processing impairments and negative symptoms in schizophrenia.

Gregory P Strauss, Lauren Luther, Ian M Raugh, Shiyuan Zhang, Sierra A Jarvis, Anna R Knippenberg, Ada L Hutcheson, Alex S Cohen

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In one paragraph

Article in Schizophrenia research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Gregory P StraussDepartment of Psychology, University of Georgia, Athens, GA, USA. Electronic address: gstrauss@uga.edu.
Lauren LutherDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Ian M RaughDepartment of Psychology, University of Georgia, Athens, GA, USA.
Shiyuan ZhangDepartment of Psychology, University of Georgia, Athens, GA, USA.
Sierra A JarvisDepartment of Psychology, University of Georgia, Athens, GA, USA.
Anna R KnippenbergDepartment of Psychology, University of Georgia, Athens, GA, USA.
Ada L HutchesonDepartment of Psychology, University of Georgia, Athens, GA, USA.
Alex S CohenDepartment of Psychology, Louisiana State University, Baton Rouge, LA, USA.

Funding

Cognitive Training for Emotion Regulation in Psychotic DisordersR61MH121560 · NIMH · UNIVERSITY OF GEORGIA · PI STRAUSS, GREGORY P · 2020 to 2021
$1.2M
Computationally modeling the failure of effort to become a secondary reinforcer in schizophreniaR21MH122863 · NIMH · UNIVERSITY OF GEORGIA · PI SHENHAV, AMITAI, STRAUSS, GREGORY P · 2020 to 2020
$441k
Modeling Anhedonia in Schizophrenia: A Stochastic Dynamical Systems ApproachR21MH112925 · NIMH · UNIVERSITY OF GEORGIA · PI STRAUSS, GREGORY P · 2017 to 2018
$417k
NIMH NIH HHS R21 MH112925NIMH NIH HHS R21 MH122863NIMH NIH HHS R61 MH121560
6 · The paper itself

Abstract

backgroundAn environmental systems theory was recently proposed positing that negative symptoms of schizophrenia (SZ) are influenced by direct and indirect environmental factors that limit access to resources needed to complete social, recreational, and goal-directed activities.

methodTwo studies were conducted to test key tenets of this theory. In each study, the Area Deprivation Index (ADI), an objective measure of resource deprivation, was calculated based on neighborhood-level geocoded data. Study 1 included healthy controls (CN: n = 78) and outpatients with schizophrenia (SZ: n = 114) who received clinical ratings of negative symptoms. Trait-level ADI scores were derived from home addresses at the time of testing. In Study 2, outpatients with SZ (n = 52) completed 1-week of digital phenotyping and a battery of laboratory-based reward processing tasks putatively related to the mechanisms underlying negative symptoms. ADI scores were derived at the state level using GPS coordinates at the time of ecological momentary assessment survey.

resultsAcross studies, greater resource deprivation measured via the ADI was associated with higher severity of negative symptoms and reward processing deficits.

conclusionsFindings indicate that environmental factors restricting access to resources are associated with negative symptoms and their underlying mechanisms in SZ. Environmental systems-focused interventions may offer a promising adjunctive treatment for negative symptoms when combined with pharmacological and psychosocial approaches.

Indexed as

RewardSchizophreniaSchizophrenic PsychologyAdultEcological Momentary AssessmentFemaleHumansMaleMiddle AgedResidence CharacteristicsAlogiaAnhedoniaAsocialityAvolitionBlunted affectEnvironment

Identifiers

PMID40749303
PMCPMC13249520

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.