Evidence map›Paper›PMID 40749113›Full record

ArticleParasite (Paris, France)2025

Isolation of Toxoplasma gondii from the placenta of northern fur seals (Callorhinus ursinus) and potential transplacental transmission of the parasite.

Gaohui Mao, Bingyan Guo, Shanshan Xie, Yurong Yang

Abstract read
In one paragraph

Article in Parasite (Paris, France), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. First report of viableFood and waterborne parasitology · 2026
    Article
  2. Population genetic structure of zoonoticScience in One Health · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gaohui MaoCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450000, China.
Bingyan GuoCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450000, China.
Shanshan XieCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450000, China.
Yurong YangCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450000, China.ORCID 0000-0001-8971-4648

Funding

Henan Province's International Scientific and Technological Cooperation Projects 242102521041
6 · The paper itself

Abstract

Toxoplasma gondii infects almost all warm-blooded animals, including marine mammals. Toxoplasmosis has been reported in wild and captive marine mammals in North America; however, no viable T. gondii strains have been isolated from northern fur seals. In this study, reproduction and T. gondii infection status were investigated in 10 northern fur seals (Callorhinus ursinus), from tissues collected from 2012 to 2024 in China. Toxoplasma gondii infections were determined by the modified agglutination test (MAT), PCR, immunohistochemical (IHC) staining, and isolation of the parasite by bioassay in mice. MAT was performed using placenta or tissue exudates to detect anti-T. gondii IgG antibodies. Four of the 10 seals had anti-T. gondii antibodies; Toxoplasma gondii DNA was detected by PCR in placenta tissues of two of these four animals, and T. gondii antibody positive reactions were observed in four seals by IHC. A viable T. gondii strain, TgFurSealCHn1, was isolated from placenta of one seal by bioassay in mice. In all, five seals had signs of T. gondii infection, and three of them had fetal stillbirth. One stillborn fetus had T. gondii nucleic acid detected by PCR, indicating potential vertical transmission of the parasite. Multilocus genetic typing of the TgFurSealCHn1 isolate revealed ToxoDB #5 genotype, which had demonstrated avirulence in Swiss Webster outbred mice, and the ROP18/ROP5 type was 2/2. ToxoDB #5 is the dominant genotype of wild terrestrial and marine mammals in North America. This is the first report of a viable T. gondii strain isolated from northern fur seal placenta.

Indexed as

Fur SealsInfectious Disease Transmission, VerticalPlacentaPregnancy Complications, ParasiticToxoplasmaToxoplasmosis, AnimalAnimalsAntibodies, ProtozoanChinaDNA, ProtozoanFemaleMicePolymerase Chain ReactionPregnancyStillbirthAntibodies, ProtozoanDNA, ProtozoanAvirulenceFur seal (Callorhinus ursinus)IsolationToxoDB#5Toxoplasma gondii

Identifiers

PMID40749113
PMCPMC12316408

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.