Evidence map›Paper›PMID 40749106›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2025

All-Cause Mortality in People With Four-Class Drug-Resistant HIV: A Matched Cohort Analysis With Data From the PRESTIGIO Registry.

Andrea Giacomelli, Nicolò Capra, Riccardo Lolatto, Roberta Gagliardini, Tommaso Clemente, Leonardo Calza, Carlo Torti, Filippo Lagi, Chiara Fornabaio, Giulia Marchetti and 3 more

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andrea GiacomelliDepartment of Biomedical and Clinical Sciences, Università Degli Studi di Milano, Milan, Italy.ORCID 0000-0003-3685-4289
Nicolò CapraIRCCS Ospedale San Raffaele, Infectious Diseases Unit, Milan, Italy.ORCID 0000-0003-1974-2015
Riccardo LolattoIRCCS Ospedale San Raffaele, Infectious Diseases Unit, Milan, Italy.
Roberta GagliardiniImmunodeficiency Unit, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Tommaso ClementeIRCCS Ospedale San Raffaele, Infectious Diseases Unit, Milan, Italy.ORCID 0000-0001-6548-3427
Leonardo CalzaDepartment of Medical and Surgical Sciences, Unit of Infectious Diseases, S. Orsola Hospital, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Carlo TortiInfectious Diseases Unit, Agostino Gemelli; University Hospital, Rome, Italy.
Filippo LagiInfectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
Chiara FornabaioInfectious Diseases Unit, ASST Cremona, Cremona, Italy.
Giulia MarchettiClinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Milan, Italy.ORCID 0000-0002-4498-4828
Giancarlo OrofinoDivision I of Infectious and Tropical Diseases, ASL Città di Torino, Torino, Italy.
Vincenzo SpagnuoloIRCCS Ospedale San Raffaele, Infectious Diseases Unit, Milan, Italy.ORCID 0000-0002-9656-7217
for PRESTIGIO Study Group

Funding

Gilead SciencesJanssen-CilagMerck Sharp & DohmePRESTIGIO registryViiV Healthcare
6 · The paper itself

Abstract

People with human immunodeficiency virus (HIV) (PWH) with 4-drug class resistance (4DR) had a higher risk of death than non-4DR PWH, primarily due to lower CD4 cell counts. The priority for this vulnerable population is achieving virological control to enable immune recovery.

Indexed as

Anti-HIV AgentsDrug Resistance, Multiple, ViralDrug Resistance, ViralHIV InfectionsAdultCD4 Lymphocyte CountCohort StudiesFemaleHumansMaleMiddle AgedRegistriesAnti-HIV Agentsdeathheavily treatment experiencedimmune suppressionmultidrug resistanceoutcome

Identifiers

PMID40749106
PMCPMC12728292

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.