Evidence map›Paper›PMID 40749059›Full record

ArticleScience advances2025

Glia-derived noncanonical fatty acid binding protein modulates brain lipid storage and clearance.

Jun Yin, Hsueh-Ling Chen, Anna Grigsby-Brown, Yi He, Myriam L Cotten, Jacob Short, Aidan Dermady, Jingce Lei, Mary Gibbs, Ethan S Cheng and 12 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Jun YinDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-4314-4402
Hsueh-Ling ChenDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0003-5002-0923
Anna Grigsby-BrownDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-1525-5132
Yi HeFermentation Facility, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-4261-9990
Myriam L CottenDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0002-6732-1736
Jacob ShortDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-5740-3535
Aidan DermadyDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-0815-0180
Jingce LeiDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-4114-6044
Mary GibbsDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0008-8270-2984
Ethan S ChengDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Dean ZhangDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Caixia LongDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0009-3006-1684
Jennifer TabetDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0009-6551-396X
Lele XuAdvanced Science Research Center, The City University of New York, New York, NY 10031, USA.ORCID 0009-0008-1141-2998
Tiffany ZhongDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Rinat AbzalimovAdvanced Science Research Center, The City University of New York, New York, NY 10031, USA.ORCID 0000-0003-2110-1532
Mariam HaiderDepartment of Cell and Developmental Biology, Vanderbilt Brain Institute, Center for Structural Biology, Vanderbilt Kennedy Center, Vanderbilt University, Nashville, TN 37203, USA.
Rong SunDepartment of Cell and Developmental Biology, Vanderbilt Brain Institute, Center for Structural Biology, Vanderbilt Kennedy Center, Vanderbilt University, Nashville, TN 37203, USA.ORCID 0000-0002-0950-1480
Ye HeAdvanced Science Research Center, The City University of New York, New York, NY 10031, USA.ORCID 0000-0002-3936-4958
Qiangjun ZhouDepartment of Cell and Developmental Biology, Vanderbilt Brain Institute, Center for Structural Biology, Vanderbilt Kennedy Center, Vanderbilt University, Nashville, TN 37203, USA.ORCID 0000-0003-1789-9588
Nico TjandraLaboratory of Molecular Biophysics, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-6365-5811
Quan YuanDendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-0676-2079

Funding

Study dendrite morphogenesis and activity-dependent plasticity using DrosophilaZIANS003137 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI YUAN, QUAN · 2013 to 2025
$24.9M
Synaptic nanostructure and dysfunction in neurodevelopmental disordersR01MH132918 · NIMH · VANDERBILT UNIVERSITY · PI Qiangjun Zhou · 2024 to 2026
$1.8M
Molecular Mechanism and Regulation of Asynchronous ReleaseR00MH113764 · NIMH · VANDERBILT UNIVERSITY · PI ZHOU, QIANGJUN · 2020 to 2022
$719k
Metabolomic interrogation of gut mechanosensing in DrosophilaR21AG086903 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALKEMA, MARK, HE, YE · 2024 to 2025
$464k
Intramural NIH HHS ZIA NS003137NIA NIH HHS R21 AG086903NIMH NIH HHS R00 MH113764NIMH NIH HHS R01 MH132918
6 · The paper itself

Abstract

Glia-derived secretory factors are essential for brain development, physiology, and homeostasis, with their dysfunction linked to a variety of neurological disorders. Through genetic and biochemical approaches, we identified odorant binding protein 44a (Obp44a), a noncanonical α-helical fatty acid binding protein (FABP) highly expressed in

Indexed as

BrainDrosophila ProteinsFatty Acid-Binding ProteinsLipid MetabolismNeurogliaAnimalsDrosophila melanogasterFatty AcidsNeuronsDrosophila ProteinsFatty Acid-Binding ProteinsFatty Acids

Identifiers

PMID40749059
PMCPMC12315990

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.