Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors.
Manuel M Gómez de Las HerasTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID 0000-0001-7447-694X
Elisa CarrascoTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID 0000-0002-0817-1627
Mario Pérez-ManriqueTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID 0009-0000-9784-8419
Naohiro InoharaDepartment of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-4215-9349
Sandra Delgado-PulidoTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID 0000-0003-2055-6594
Álvaro Fernández-AlmeidaTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID 0009-0006-1483-4585
María I Gálvez-CastañoTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Isaac Francos-QuijornaTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID 0000-0003-2514-4206
Carolina SimóMolecular Nutrition and Metabolism, Institute of Food Science Research (CIAL), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID 0000-0002-7140-0795
Virginia García-CañasMolecular Nutrition and Metabolism, Institute of Food Science Research (CIAL), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID 0000-0001-6728-4325
José Ignacio Escrig-LarenaTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID 0000-0002-1538-8808
Juan Francisco ArandaDepartment of Genetics, Physiology, and Microbiology, Faculty of Biological Sciences, Complutense University of Madrid (UCM), Madrid, Spain.ORCID 0000-0002-5598-2465
Gonzalo Soto-HerederoTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID 0000-0001-8043-7314
Enrique Gabandé-RodríguezTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID 0000-0002-9715-8714
Eva María BlancoTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Joyce Días-AlmeidaDepartment of Biology, Faculty of Sciences, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Gabriel NúñezDepartment of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-6529-2695
María MittelbrunnTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID 0000-0003-3487-8762
Funding
Role of Immunity and the Microbiota in Enteropathogenic E. coli EradicationR01DK095782 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NUNEZ, GABRIEL · 2013 to 2022
$3.6M
European Research Council 101044248NIDDK NIH HHS R01 DK095782
6 · The paper itself
Abstract
Healthy aging relies on a symbiotic host-microbiota relationship. The age-associated decline of the immune system can pose a threat to this delicate equilibrium. In this work, we investigated how the functional deterioration of T cells can affect host-microbiota symbiosis and gut barrier integrity and the implications of this deterioration for inflammaging, senescence, and health decline. Using the
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity. · full record | OpenQuestion